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Nyx Gene Detail
Summary
  • Symbol
    Nyx
  • Name
    nyctalopin
  • Synonyms
    CLNP, CSNB1, CSNB4, MGC:38926, nob
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448607
    NCBI Gene: 236690
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:13332349-13355552 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 8.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448607
 protein coding gene ChrX:13327097-13359059 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035572
 protein coding gene ChrX:8329861-8354165 (+)
A/J MGP_AJ_G0035550
 protein coding gene ChrX:8407858-8430998 (+)
AKR/J MGP_AKRJ_G0035482
 protein coding gene ChrX:8692154-8716593 (+)
BALB/cJ MGP_BALBcJ_G0035543
 protein coding gene ChrX:8265737-8290732 (+)
C3H/HeJ MGP_C3HHeJ_G0035259
 protein coding gene ChrX:8433047-8456261 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036072
 protein coding gene ChrX:8533949-8560306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032942
 protein coding gene ChrX:7304264-7326560 (+)
CAST/EiJ MGP_CASTEiJ_G0034551
 protein coding gene ChrX:8163115-8185540 (+)
CBA/J MGP_CBAJ_G0035228
 protein coding gene ChrX:8971650-8996742 (+)
DBA/2J MGP_DBA2J_G0035381
 protein coding gene ChrX:8249461-8272587 (+)
FVB/NJ MGP_FVBNJ_G0035328
 protein coding gene ChrX:8084864-8108323 (+)
LP/J MGP_LPJ_G0035463
 protein coding gene ChrX:8502052-8525274 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035371
 protein coding gene ChrX:8880318-8903463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036084
 protein coding gene ChrX:8243959-8268268 (+)
PWK/PhJ MGP_PWKPhJ_G0034252
 protein coding gene ChrX:7729826-7758228 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034093
 protein coding gene ChrX:8340027-8363526 (+)
WSB/EiJ MGP_WSBEiJ_G0034687
 protein coding gene ChrX:8278551-8301728 (+)



Homology
more
  • Human Ortholog
    NYX, nyctalopin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NYX, nyctalopin
  • Synonyms
    CLRP, CSNB1, CSNB1A, CSNB4, NBM1
  • Links
    NCBI Gene ID: 60506
    neXtProt AC: NX_Q9GZU5
    UniProt: Q9GZU5

  • Chr Location
    Xp11.4; chrX:41447343-41475710 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nyx mouse models; 2 with human NYX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation fail to display the dark-adapted electroretinographic b-wave, and exhibit abnormal rod and cone electrophysiology, and absent visual evoked potential.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051228 Ensembl Gene Model | MGI Sequence Detail 23204 C57BL/6J ±  kb
    transcript ENSMUST00000050434 Ensembl | MGI Sequence Detail 5183 Not Applicable  
    polypeptide ENSMUSP00000056313 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1328327
    References
    more
    • Summaries
      All 43
      Diseases 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
    • Latest
      J:322825 Holzel MB, et al., Receptive Field Sizes of Nyx(nob) Mouse Retinal Ganglion Cells. Int J Mol Sci. 2022 Mar 16;23(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory