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Akap8 Gene Detail
Summary
  • Symbol
    Akap8
  • Name
    A kinase anchor protein 8
  • Synonyms
    1200016A02Rik, AKAP95
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928488
    NCBI Gene: 56399
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32522646-32540212 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.48 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    458 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928488
 protein coding gene Chr17:32522646-32540212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023501
 protein coding gene Chr17:32145733-32163223 (-)
A/J MGP_AJ_G0023458
 protein coding gene Chr17:31077163-31094601 (-)
AKR/J MGP_AKRJ_G0023424
 protein coding gene Chr17:31361411-31378746 (-)
BALB/cJ MGP_BALBcJ_G0023463
 protein coding gene Chr17:31170660-31188351 (-)
C3H/HeJ MGP_C3HHeJ_G0023225
 protein coding gene Chr17:31760813-31779736 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023906
 protein coding gene Chr17:33235630-33253075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021380
 protein coding gene Chr17:28176618-28194729 (-)
CAST/EiJ MGP_CASTEiJ_G0022726
 protein coding gene Chr17:31814510-31831926 (-)
CBA/J MGP_CBAJ_G0023200
 protein coding gene Chr17:34699758-34717164 (-)
DBA/2J MGP_DBA2J_G0023330
 protein coding gene Chr17:30453902-30471514 (-)
FVB/NJ MGP_FVBNJ_G0023300
 protein coding gene Chr17:30279286-30297839 (-)
LP/J MGP_LPJ_G0023408
 protein coding gene Chr17:32363006-32380380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023318
 protein coding gene Chr17:33758230-33775615 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023948
 protein coding gene Chr17:31719188-31737132 (-)
PWK/PhJ MGP_PWKPhJ_G0022475
 protein coding gene Chr17:29346315-29364903 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022294
 protein coding gene Chr17:29739894-29757486 (-)
WSB/EiJ MGP_WSBEiJ_G0022788
 protein coding gene Chr17:31702446-31721269 (-)



Homology
more
  • Human Ortholog
    AKAP8, A-kinase anchoring protein 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP8, A-kinase anchoring protein 8
  • Synonyms
    AKAP-8, AKAP 95, AKAP-95, AKAP95
  • Links
    NCBI Gene ID: 10270
    neXtProt AC: NX_O43823
    UniProt: O43823

  • Chr Location
    19p13.12; chr19:15353385-15379815 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    1 images
    11 phenotype references
Mice homozygous for a gene trap insertion are viable and overtly normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    124
  • cDNA Data
    224
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56399 NCBI Gene Model | MGI Sequence Detail 17567 C57BL/6J ±  kb
transcript NR_131218 RefSeq | MGI Sequence Detail 4690 Not Specified  
polypeptide Q9DBR0 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000003894 A-kinase anchor protein 8
    (term hierarchy)
  • InterPro Domains
    IPR007071 A-kinase anchoring protein 95 (AKAP95)
    IPR034736 Zinc finger C2H2 AKAP95-type
  • GlyGen
    Q9DBR0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 227
    cDNA 225
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1914712, MGI:2146780, MGI:2146969
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:294997 Li W, et al., Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. Nat Cell Biol. 2020 Aug;22(8):960-972
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory