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Btc Gene Detail
Summary
  • Symbol
    Btc
  • Name
    betacellulin, epidermal growth factor family member
  • Feature Type
    protein coding gene
  • IDs
    MGI:99439
    NCBI Gene: 12223
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91505120-91550853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99439
protein coding gene Chr5:91505120-91550853 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029737
protein coding gene Chr5:92442396-92489578 (-)
A/J MGP_AJ_G0029703
protein coding gene Chr5:88821849-88868761 (-)
AKR/J MGP_AKRJ_G0029649
protein coding gene Chr5:91697062-91740389 (-)
BALB/cJ MGP_BALBcJ_G0029713
protein coding gene Chr5:89694020-89738110 (-)
C3H/HeJ MGP_C3HHeJ_G0029436
protein coding gene Chr5:92096288-92143292 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030167
protein coding gene Chr5:96145751-96197669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027403
protein coding gene Chr5:84489139-84531997 (-)
CAST/EiJ MGP_CASTEiJ_G0028846
protein coding gene Chr5:91469944-91519576 (-)
CBA/J MGP_CBAJ_G0029406
protein coding gene Chr5:99421937-99477510 (-)
DBA/2J MGP_DBA2J_G0029550
protein coding gene Chr5:88869050-88915950 (-)
FVB/NJ MGP_FVBNJ_G0029509
protein coding gene Chr5:87718946-87764768 (-)
LP/J MGP_LPJ_G0029638
protein coding gene Chr5:92834962-92881850 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029538
protein coding gene Chr5:104412079-104465247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030201
protein coding gene Chr5:91232848-91281921 (-)
PWK/PhJ MGP_PWKPhJ_G0028565
protein coding gene Chr5:87934071-87978694 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028400
protein coding gene Chr5:90620032-90667434 (-)
WSB/EiJ MGP_WSBEiJ_G0028925
protein coding gene Chr5:91685255-91732637 (-)



Homology
more
  • Human Ortholog
    BTC, betacellulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTC, betacellulin
  • Links
    NCBI Gene ID: 685
    neXtProt AC: NX_P35070
    UniProt: P35070

  • Chr Location
    4q13.3; chr4:74744759-74794523 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human BTC associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    51 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit no overt defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12223 NCBI Gene Model | MGI Sequence Detail 45734 C57BL/6J ±  kb
    transcript NM_007568 RefSeq | MGI Sequence Detail 2876 ZRU/MplStud  
    polypeptide Q05928 UniProt | EBI | MGI Sequence Detail 177 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16203
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:334091 Zhang X, et al., Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain. iScience. 2023 Mar 17;26(3):106242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory