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n-TUtca2 Gene Detail
Summary
  • Symbol
    n-TUtca2
  • Name
    nuclear encoded tRNA selenocysteine 2 (anticodon TCA)
  • Synonyms
    opal suppressor, selenocysteine tRNA, trna86-SeC(e)TCA, tRNA Sec, Trnau1, Trsp
  • Feature Type
    tRNA gene
  • IDs
    MGI:4414022
    NCBI Gene: 22069
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19035169-19035255 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.56 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_4414022
 tRNA gene Chr7:19035169-19035255 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Human Diseases
more
  • Diseases
    1 with n-TUtca2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 6 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations that inactivate the gene die shortly after implantation. Selective disruption of the gene in mammary epithial tissue did not impair lactation or mammary development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    6
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
  • Literature Summary
    1
  • Other Mouse Links
    GEO
Sequences &
Gene Models
less
  • All Sequences
    5
Representative SequencesLengthStrain/SpeciesFlank
genomic 22069 NCBI Gene Model | MGI Sequence Detail 87 C57BL/6J ±  kb
transcript L14949 GenBank | ENA | DDBJ | MGI Sequence Detail 90 Not Specified  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 4
    Genomic 2
    cDNA 1
    Other 1
Other
Accession IDs
less
MGD-MRK-15251, MGI:98837
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 35
  • Earliest
    J:1449 Mizutani T, et al., Some properties of murine selenocysteine synthase [published erratum appears in Biochem J 1992 Dec 15;288(Pt 3):1077]. Biochem J. 1992 Jun 15;284(Pt 3):827-34
  • Latest
    J:331488 Lee TJ, et al., The role of selenoproteins in neutrophils during inflammation. Arch Biochem Biophys. 2022 Nov 3;732:109452
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory