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T Gene Detail
Summary
  • Symbol
    T
  • Name
    brachyury, T-box transcription factor T
  • Synonyms
    Bra, T1, Tbxt
  • Feature Type
    protein coding gene
  • IDs
    MGI:98472
    NCBI Gene: 20997
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8653255-8661328 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 4.92 cM
  • Mapping Data
    105 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98472
protein coding gene Chr17:8653255-8661328 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023135
protein coding gene Chr17:5909127-5917200 (+)
A/J MGP_AJ_G0023103
protein coding gene Chr17:5931710-5939667 (+)
AKR/J MGP_AKRJ_G0023067
protein coding gene Chr17:5619204-5629048 (+)
BALB/cJ MGP_BALBcJ_G0023103
protein coding gene Chr17:5729799-5737873 (+)
C3H/HeJ MGP_C3HHeJ_G0022866
protein coding gene Chr17:5884583-5892658 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023546
protein coding gene Chr17:6199259-6207326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021061
protein coding gene Chr17:8427938-8435930 (-)
CAST/EiJ MGP_CASTEiJ_G0022380
protein coding gene Chr17:5864956-5872961 (+)
CBA/J MGP_CBAJ_G0022838
protein coding gene Chr17:6406526-6414606 (+)
DBA/2J MGP_DBA2J_G0022971
protein coding gene Chr17:5597457-5605939 (+)
FVB/NJ MGP_FVBNJ_G0022940
protein coding gene Chr17:5527487-5535375 (+)
LP/J MGP_LPJ_G0023042
protein coding gene Chr17:5736949-5744930 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022960
protein coding gene Chr17:6142844-6152293 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023572
protein coding gene Chr17:5897273-5906478 (+)
PWK/PhJ MGP_PWKPhJ_G0022128
protein coding gene Chr17:5231769-5239940 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021958
protein coding gene Chr17:5165711-5173703 (+)
WSB/EiJ MGP_WSBEiJ_G0022437
protein coding gene Chr17:6199707-6207595 (+)



Homology
more
  • Human Ortholog
    TBXT, T-box transcription factor T
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBXT, T-box transcription factor T
  • Synonyms
    SAVA, T, TFT
  • Links
    NCBI Gene ID: 6862
    neXtProt AC: NX_O15178
    UniProt: O15178

  • Chr Location
    6q27; chr6:166157656-166168700 (-)  GRCh38

  • MGI Vertebrate Homology
    T stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: TBXT
  • Gene Tree
    T
Human Diseases
more
  • Diseases
    1 with human TBXT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 28 alleles in 22 genetic backgrounds
    72 phenotypes from multigenic genotypes
    3 images
    454 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice die during embryonic development. Heterozygous mice have skeletal abnormalities. On specific genetic backgrounds, some alleles cause partial or complete sex-reversal of chromosomally XY mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20997 NCBI Gene Model | MGI Sequence Detail 8074 C57BL/6J ±  kb
    transcript NM_009309 RefSeq | MGI Sequence Detail 2046 ZRU/MplStud  
    polypeptide P20293 UniProt | EBI | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      Genomic 4
      cDNA 57
      Primer pair 39
      Other 81

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11865, MGD-MRK-11883, MGD-MRK-14695, MGD-MRK-2096, MGI:2152887, MGI:2152888
    References
    more
    • Summaries
      All 1228
      Developmental Gene Expression 624
      Diseases 6
      Gene Ontology 24
      Phenotypes 454
    • Earliest
      J:14909 Dobrovolskaia-Zavadskaia N, Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere (facteur) hereditaire "non-viable". C R Seances Soc Biol Fil. 1927;97:114-16
    • Latest
      J:345569 Brandauer J, et al., Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling. Am J Physiol Regul Integr Comp Physiol. 2024 Feb 1;326(2):R176-R183

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory