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Serpina3m Gene Detail
Summary
  • Symbol
    Serpina3m
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3M
  • Synonyms
    3e46, alpha-1 antiproteinase, antitrypsin, contrapsin-like, MMCM7, MMSPi2.4, Spi2.4, Spi-2l, Spi-2rs1, Spi2-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98378
    NCBI Gene: 20717
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104353424-104360518 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 54.12 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98378
 protein coding gene Chr12:104304745-104360518 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020075
 protein coding gene Chr12:106178147-106185239 (+)
A/J MGP_AJ_G0020029
 protein coding gene Chr12:102100750-102154957 (+)
AKR/J MGP_AKRJ_G0020006
 protein coding gene Chr12:105011319-105100443 (+)
BALB/cJ MGP_BALBcJ_G0020015
 protein coding gene Chr12:102481456-102565546 (+)
C3H/HeJ MGP_C3HHeJ_G0019818
 protein coding gene Chr12:105556891-105563984 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020461
 protein coding gene Chr12:109439002-109496795 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018074
 protein coding gene Chr12:98860602-98867373 (+)
CAST/EiJ MGP_CASTEiJ_G0019354
 protein coding gene Chr12:100038276-100043570 (-)
CBA/J MGP_CBAJ_G0019785
 protein coding gene Chr12:113587962-113698740 (+)
DBA/2J MGP_DBA2J_G0019902
 protein coding gene Chr12:101608994-101697943 (+)
FVB/NJ MGP_FVBNJ_G0019887
 protein coding gene Chr12:100472834-100479345 (+)
LP/J MGP_LPJ_G0019977
 protein coding gene Chr12:105959395-106053357 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019925
 protein coding gene Chr12:117175034-117180057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020490
 protein coding gene Chr12:104473474-104531444 (+)
PWK/PhJ MGP_PWKPhJ_G0019121
 protein coding gene Chr12:96152107-96206855 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018924
 protein coding gene Chr12:98779539-98784396 (+)
WSB/EiJ MGP_WSBEiJ_G0019418
 protein coding gene Chr12:105404335-105496033 (+)



Homology
more
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA3, serpin family A member 3
  • Synonyms
    AACT, ACT, GIG24, GIG25
  • Links
    NCBI Gene ID: 12
    neXtProt AC: NX_P01011
    UniProt: P01011

  • Chr Location
    14q32.13; chr14:94612384-94624055 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SERPINA3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    7
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20717 NCBI Gene Model | MGI Sequence Detail 7095 C57BL/6J ±  kb
transcript NM_009253 RefSeq | MGI Sequence Detail 1660 C57BL/6  
polypeptide Q03734 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14522, MGD-MRK-14524, MGD-MRK-14527, MGI:2144772
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:11249 Ohkubo K, et al., Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Biochem J. 1991 Jun 1;276(Pt 2):337-42
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory