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C4a Gene Detail
Summary
  • Symbol
    C4a
  • Name
    complement C4A (Rodgers blood group)
  • Synonyms
    Slp
Location &
Maps
more
  • Sequence Map
    Chr17:35028069-35042436 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.37 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    7
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98320
protein coding gene Chr17:35028069-35042440 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015350
unclassified non-coding RNA gene Chr17:34826626-34933666 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0015288
unclassified non-coding RNA gene Chr17:34058869-34244791 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0013483
unclassified non-coding RNA gene Chr17:31527032-31542709 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0015266
unclassified non-coding RNA gene Chr17:35211346-35240269 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015219
unclassified non-coding RNA gene Chr17:36520117-36521624 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0014770
unclassified non-coding RNA gene Chr17:34478931-34496289 (-)



Homology
more
  • Human Ortholog
    C4A, complement C4A (Chido/Rodgers blood group)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C4A, complement C4A (Chido/Rodgers blood group)
  • Synonyms
    C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
  • Links
    NCBI Gene ID: 720
    neXtProt AC: NX_P0C0L4
    UniProt: P0C0L4

  • Chr Location
    6p21.33; chr6:31982057-32002681 (+)  GRCh38

  • Human Ortholog
    C4B, complement C4B (Chido/Rodgers blood group)
  • Synonyms
    C4B1, C4B12, C4B2, C4B_2, C4B3, C4B5, C4BD, C4F, CH, CO4, CPAMD3
  • Links
    NCBI Gene ID: 721
    neXtProt AC: NX_P0C0L4, NX_P0C0L5
    UniProt: P0C0L5

  • Chr Location
    6p21.33; chr6:32014795-32035418 (+)  GRCh38

Human Diseases
more
  • Diseases
    8 with human C4A,C4B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 625018 NCBI Gene Model | MGI Sequence Detail 14368 C57BL/6J ±  kb
transcript NM_011413 RefSeq | MGI Sequence Detail 5369 Not Specified  
polypeptide NP_035543 RefSeq | MGI Sequence Detail 1735 Not Specified  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 87
    Genomic 71
    cDNA 14
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14443
References
more
  • Summaries
    All 68
    Gene Ontology 4
  • Earliest
    J:5181 Passmore HC, et al., A sex-limited serum protein variant in the mouse: inheritance and association with the H-2 region. Biochem Genet. 1970 Jun;4(3):351-65
  • Latest
    J:305232 Yilmaz M, et al., Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat Neurosci. 2021 Feb;24(2):214-224

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory