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Ptprs Gene Detail
Summary
  • Symbol
    Ptprs
  • Name
    protein tyrosine phosphatase receptor type S
  • Synonyms
    PTP-NU3, PTPsigma, Ptpt9, RPTPsigma
  • Feature Type
    protein coding gene
  • IDs
    MGI:97815
    NCBI Gene: 19280
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56719426-56783480 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.32 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97815
 protein coding gene Chr17:56719426-56783483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023926
 protein coding gene Chr17:58106920-58174240 (-)
A/J MGP_AJ_G0023884
 protein coding gene Chr17:56514123-56577963 (-)
AKR/J MGP_AKRJ_G0023853
 protein coding gene Chr17:57210781-57276212 (-)
BALB/cJ MGP_BALBcJ_G0023885
 protein coding gene Chr17:56336160-56400335 (-)
C3H/HeJ MGP_C3HHeJ_G0023649
 protein coding gene Chr17:57936006-58001410 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024331
 protein coding gene Chr17:60372433-60436088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021777
 protein coding gene Chr17:52999142-53062990 (-)
CAST/EiJ MGP_CASTEiJ_G0023131
 protein coding gene Chr17:58228812-58291833 (-)
CBA/J MGP_CBAJ_G0023625
 protein coding gene Chr17:62716034-62789369 (-)
DBA/2J MGP_DBA2J_G0023753
 protein coding gene Chr17:55222454-55285989 (-)
FVB/NJ MGP_FVBNJ_G0023719
 protein coding gene Chr17:54752583-54817432 (-)
LP/J MGP_LPJ_G0023835
 protein coding gene Chr17:58791191-58858531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023747
 protein coding gene Chr17:62213317-62276779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024375
 protein coding gene Chr17:57579675-57644504 (-)
PWK/PhJ MGP_PWKPhJ_G0022877
 protein coding gene Chr17:54576980-54640816 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022688
 protein coding gene Chr17:54332381-54397869 (-)
WSB/EiJ MGP_WSBEiJ_G0023197
 protein coding gene Chr17:58184199-58251021 (-)



Homology
more
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase receptor type S
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase receptor type S
  • Synonyms
    PTPSIGMA, R-PTP-S, R-PTP-sigma
  • Links
    NCBI Gene ID: 5802
    neXtProt AC: NX_Q13332
    UniProt: Q13332

  • Chr Location
    19p13.3; chr19:5158495-5340812 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    59 phenotypes from multigenic genotypes
    5 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Almost half of null homozygotes die in the first day of life. Embryos are characterized by decreased brain size including small pituitary glands and small olfactory bulbs. Adult mice are small, lack estrus, have decreased litter sizes and have impairedolfaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1073
  • Tissues
    159
  • cDNA Data
    417
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19280 NCBI Gene Model | MGI Sequence Detail 64055 C57BL/6J ±  kb
    transcript NM_011218 RefSeq | MGI Sequence Detail 6874 ZRU/MplStud  
    polypeptide B0V2N1 UniProt | EBI | MGI Sequence Detail 1907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 421
      cDNA 419
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13684, MGI:2146946
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 16
      Phenotypes 42
    • Earliest
      J:4150 Schepens J, et al., Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Mol Biol Rep. 1992 Sep;16(4):241-8
    • Latest
      J:339266 Sclip A, et al., Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit. Nat Commun. 2023 Aug 17;14(1):4976
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory