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Ptger3 Gene Detail
Summary
  • Symbol
    Ptger3
  • Name
    prostaglandin E receptor 3 (subtype EP3)
  • Synonyms
    EP3, Pgerep3, Ptgerep3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97795
    NCBI Gene: 19218
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:157272459-157350392 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 81.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1966 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97795
 protein coding gene Chr3:157272459-157351525 (+)
129S1/SvImJ ENSMUSG00200000081
 protein coding gene Chr3:154269229-154348221 (+)
A/J ENSMUSG00195002660
 protein coding gene Chr3:154396055-154475035 (+)
AKR/J ENSMUSG00220011075
 protein coding gene Chr3:152815970-152894932 (+)
BALB/cJ ENSMUSG00180006597
 protein coding gene Chr3:154247767-154326739 (+)
C3H/HeJ ENSMUSG00175003260
 protein coding gene Chr3:153864281-153943251 (+)
C57BL/6NJ ENSMUSG00215004214
 protein coding gene Chr3:154479326-154558329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025764
 protein coding gene Chr3:150436135-150518381 (+)
CAST/EiJ ENSTCUG00005000044
 protein coding gene Chr3:154906092-154987056 (+)
CBA/J ENSMUSG00210000351
 protein coding gene Chr3:154494512-154573488 (+)
DBA/2J ENSMUSG00185000042
 protein coding gene Chr3:155145171-155224146 (+)
FVB/NJ ENSMUSG00205008590
 protein coding gene Chr3:153407435-153486410 (+)
JF1/MsJ ENSUMUG00000000056
 protein coding gene Chr3:153893542-153977313 (+)
LP/J ENSMUSG00230009440
 protein coding gene Chr3:157018126-157097110 (+)
NOD/ShiLtJ ENSMUSG00190007484
 protein coding gene Chr3:155497612-155576565 (+)
NZO/HlLtJ ENSMUSG00225004966
 protein coding gene Chr3:159539592-159618566 (+)
PWK/PhJ ENSLUMG00010000047
 protein coding gene Chr3:153832545-153912926 (+)
SPRET/EiJ ENSMSPG00010000282
 protein coding gene Chr3:155193764-155276319 (+)
WSB/EiJ ENSIUOG00005003368
 protein coding gene Chr3:154633037-154713426 (+)



Homology
more
  • Human Ortholog
    PTGER3, prostaglandin E receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGER3, prostaglandin E receptor 3
  • Synonyms
    EP3, EP3e, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, lnc003875, PGE2-R
  • Links
    NCBI Gene ID: 5733
    UniProt: P43115

  • Chr Location
    1p31.1; chr1:70852353-71047816 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTGER3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 8 genetic backgrounds
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    58
  • cDNA Data
    14
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19218 NCBI Gene Model | MGI Sequence Detail 77934 C57BL/6J ±  kb
    transcript NM_001359745 RefSeq | MGI Sequence Detail 2120 ZRU/MplStud  
    polypeptide P30557 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 15
      Primer pair 5
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13257, MGD-MRK-13662
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 8
      Gene Ontology 19
      Phenotypes 107
    • Earliest
      J:150 Sugimoto Y, et al., Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype. J Biol Chem. 1992 Apr 5;267(10):6463-6
    • Latest
      J:375546 Machado NLS, et al., Preoptic EP3R neurons constitute a two-way switch for fever and torpor. Nature. 2025 Aug;644(8076):463-472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory