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Proc Gene Detail
Summary
  • Symbol
    Proc
  • Name
    protein C
  • Synonyms
    inactivator of coagulation factors Va, VIII, PC
  • Feature Type
    protein coding gene
  • IDs
    MGI:97771
    NCBI Gene: 19123
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32256179-32272623 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 17.94 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    133 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97771
 protein coding gene Chr18:32256179-32272623 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024224
 protein coding gene Chr18:30247716-30267275 (-)
A/J MGP_AJ_G0024190
 protein coding gene Chr18:29242357-29260001 (-)
AKR/J MGP_AKRJ_G0024159
 protein coding gene Chr18:30058606-30077040 (-)
BALB/cJ MGP_BALBcJ_G0024190
 protein coding gene Chr18:29339101-29355937 (-)
C3H/HeJ MGP_C3HHeJ_G0023958
 protein coding gene Chr18:30092611-30115475 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024632
 protein coding gene Chr18:31332164-31350929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022073
 protein coding gene Chr18:29479226-29494929 (-)
CAST/EiJ MGP_CASTEiJ_G0023433
 protein coding gene Chr18:29993049-30008453 (-)
CBA/J MGP_CBAJ_G0023926
 protein coding gene Chr18:32283836-32306543 (-)
DBA/2J MGP_DBA2J_G0024058
 protein coding gene Chr18:28916598-28933156 (-)
FVB/NJ MGP_FVBNJ_G0024024
 protein coding gene Chr18:28622977-28641453 (-)
LP/J MGP_LPJ_G0024139
 protein coding gene Chr18:30336012-30353443 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024052
 protein coding gene Chr18:33629110-33647052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024680
 protein coding gene Chr18:29914647-29933395 (-)
PWK/PhJ MGP_PWKPhJ_G0023176
 protein coding gene Chr18:29083129-29099949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022985
 protein coding gene Chr18:30158208-30176964 (-)
WSB/EiJ MGP_WSBEiJ_G0023496
 protein coding gene Chr18:29821788-29841516 (-)



Homology
more
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROC, protein C, inactivator of coagulation factors Va and VIIIa
  • Synonyms
    APC, PC, PROC1, THPH3, THPH4
  • Links
    NCBI Gene ID: 5624
    neXtProt AC: NX_P04070
    UniProt: P04070

  • Chr Location
    2q14.3; chr2:127418427-127429242 (+)  GRCh38
Human Diseases
more
  • Diseases
    13 with human PROC associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    43 phenotypes from multigenic genotypes
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    13
  • cDNA Data
    22
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19123 NCBI Gene Model | MGI Sequence Detail 16445 C57BL/6J ±  kb
    transcript NM_001042768 RefSeq | MGI Sequence Detail 1652 C57BL/6  
    polypeptide P33587 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013261 vitamin K-dependent protein C
      (term hierarchy)
    • EC
      3.4.21.69
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 23
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13625
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
    • Latest
      J:322319 Xue M, et al., Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. Int J Mol Sci. 2022 Jan 3;23(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory