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Prkce Gene Detail
Summary
  • Symbol
    Prkce
  • Name
    protein kinase C, epsilon
  • Synonyms
    5830406C15Rik, PCK epsilon, Pkce, PKC[e], PKCepsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:97599
    NCBI Gene: 18754
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:86475213-86965347 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 56.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97599
 protein coding gene Chr17:86472631-86965347 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024091
 protein coding gene Chr17:89472074-89986091 (+)
A/J MGP_AJ_G0024050
 protein coding gene Chr17:86594434-87094832 (+)
AKR/J MGP_AKRJ_G0024019
 protein coding gene Chr17:88011182-88533885 (+)
BALB/cJ MGP_BALBcJ_G0024051
 protein coding gene Chr17:86442035-86941020 (+)
C3H/HeJ MGP_C3HHeJ_G0023816
 protein coding gene Chr17:88897745-89401399 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024496
 protein coding gene Chr17:92591410-93113232 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021935
 protein coding gene Chr17:81779881-82262257 (+)
CAST/EiJ MGP_CASTEiJ_G0023295
 protein coding gene Chr17:89713927-90248352 (+)
CBA/J MGP_CBAJ_G0023790
 protein coding gene Chr17:96447618-97004324 (+)
DBA/2J MGP_DBA2J_G0023918
 protein coding gene Chr17:85054484-85547089 (+)
FVB/NJ MGP_FVBNJ_G0023884
 protein coding gene Chr17:84547877-85041588 (+)
LP/J MGP_LPJ_G0024002
 protein coding gene Chr17:90232339-90767373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023912
 protein coding gene Chr17:96426635-96945655 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024541
 protein coding gene Chr17:88540253-89060399 (+)
PWK/PhJ MGP_PWKPhJ_G0023040
 protein coding gene Chr17:84666636-85168715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022851
 protein coding gene Chr17:85325485-85862735 (+)
WSB/EiJ MGP_WSBEiJ_G0023361
 protein coding gene Chr17:89389892-89915073 (+)



Homology
more
  • Human Ortholog
    PRKCE, protein kinase C epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKCE, protein kinase C epsilon
  • Synonyms
    nPKC-epsilon, PKCE
  • Links
    NCBI Gene ID: 5581
    neXtProt AC: NX_Q02156
    UniProt: Q02156

  • Chr Location
    2p21; chr2:45651279-46187990 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1002
  • Tissues
    111
  • cDNA Data
    51
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045038 Ensembl Gene Model | MGI Sequence Detail 490135 C57BL/6J ±  kb
    transcript ENSMUST00000097274 Ensembl | MGI Sequence Detail 3161 Not Applicable  
    polypeptide ENSMUSP00000094873 Ensembl | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13331, MGI:1914847, MGI:2147156
    References
    more
    • Summaries
      All 227
      Developmental Gene Expression 22
      Gene Ontology 36
      Phenotypes 92
    • Earliest
      J:10128 Wada H, et al., Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochem Biophys Res Commun. 1989 Nov 30;165(1):533-8
    • Latest
      J:337737 Dugan MP, et al., Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain. Mol Cell Proteomics. 2023 Apr;22(4):100522
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory