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Ntsr1 Gene Detail
Summary
  • Symbol
    Ntsr1
  • Name
    neurotensin receptor 1
  • Synonyms
    NT-1R, NTR-1, NTR1, Ntsr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97386
    NCBI Gene: 18216
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180141769-180186772 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.04 cM, cytoband H1-H4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1150 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97386
 protein coding gene Chr2:180141769-180186773 (+)
129S1/SvImJ ENSMUSG00200001632
 protein coding gene Chr2:176163612-176208842 (+)
A/J ENSMUSG00195001064
 protein coding gene Chr2:176401184-176446436 (+)
AKR/J ENSMUSG00220000044
 protein coding gene Chr2:174079745-174125004 (+)
BALB/cJ ENSMUSG00180000223
 protein coding gene Chr2:174203506-174248713 (+)
C3H/HeJ ENSMUSG00175004403
 protein coding gene Chr2:175361792-175407044 (+)
C57BL/6NJ ENSMUSG00215002429
 protein coding gene Chr2:174302984-174348257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024781
 protein coding gene Chr2:170035079-170079225 (+)
CAST/EiJ ENSTCUG00005000572
 protein coding gene Chr2:173650306-173695591 (+)
CBA/J ENSMUSG00210000771
 protein coding gene Chr2:174681564-174726805 (+)
DBA/2J ENSMUSG00185019115
 protein coding gene Chr2:175921213-175966453 (+)
FVB/NJ ENSMUSG00205002163
 protein coding gene Chr2:174733275-174778532 (+)
JF1/MsJ ENSUMUG00000015877
 protein coding gene Chr2:177099164-177144516 (+)
LP/J ENSMUSG00230024792
 protein coding gene Chr2:177814571-177859805 (+)
NOD/ShiLtJ ENSMUSG00190016357
 protein coding gene Chr2:174223180-174268413 (+)
NZO/HlLtJ ENSMUSG00225006822
 protein coding gene Chr2:185901782-185947029 (+)
PWK/PhJ ENSLUMG00010000328
 protein coding gene Chr2:174525899-174571227 (+)
SPRET/EiJ ENSMSPG00010003622
 protein coding gene Chr2:177001419-177045971 (+)
WSB/EiJ ENSIUOG00005000045
 protein coding gene Chr2:174246205-174291421 (+)



Homology
more
  • Human Ortholog
    NTSR1, neurotensin receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTSR1, neurotensin receptor 1
  • Synonyms
    NTR
  • Links
    NCBI Gene ID: 4923
    UniProt: P30989

  • Chr Location
    20q13.33; chr20:62708836-62762771 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NTSR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 7 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice deficient for this marker have normal baseline prepulse inhibition responses and acoustic startle responses. Mice are heavier, eat more, and have lower body temperatures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    75
  • cDNA Data
    8
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18216 NCBI Gene Model | MGI Sequence Detail 45004 C57BL/6J ±  kb
    transcript NM_018766 RefSeq | MGI Sequence Detail 3916 Not Specified  
    polypeptide O88319 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12945
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 38
    • Earliest
      J:18220 Laurent P, et al., Chromosomal localization of mouse and human neurotensin receptor genes. Mamm Genome. 1994 May;5(5):303-6
    • Latest
      J:390514 Pauli JL, et al., Parabrachial Ntsr1 neurons modulate food intake and anxiety through a projection to the ventromedial hypothalamus. Proc Natl Acad Sci U S A. 2026 Jul 28;123(30):e2605466123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory