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Blnk Gene Detail
Summary
  • Symbol
    Blnk
  • Name
    B cell linker
  • Synonyms
    BASH, Bca, BCA, BLNK, Ly-57, Ly57, SLP-65
  • Feature Type
    protein coding gene
  • IDs
    MGI:96878
    NCBI Gene: 17060
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:40917371-40982664 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2322 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96878
 protein coding gene Chr19:40917371-40982978 (-)
129S1/SvImJ ENSMUSG00200028804
 protein coding gene Chr19:37658752-37724351 (-)
A/J ENSMUSG00195011385
 protein coding gene Chr19:37758767-37824398 (-)
AKR/J ENSMUSG00220018156
 protein coding gene Chr19:37575484-37641101 (-)
BALB/cJ ENSMUSG00180030997
 protein coding gene Chr19:38011187-38076809 (-)
C3H/HeJ ENSMUSG00175040710
 protein coding gene Chr19:37537853-37603391 (-)
C57BL/6NJ ENSMUSG00215021191
 protein coding gene Chr19:37606674-37672290 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022945
 protein coding gene Chr19:37614908-37680209 (-)
CAST/EiJ ENSTCUG00005013454
 protein coding gene Chr19:37223885-37287211 (-)
CBA/J ENSMUSG00210027644
 protein coding gene Chr19:37620021-37685544 (-)
DBA/2J ENSMUSG00185029304
 protein coding gene Chr19:38140182-38205713 (-)
FVB/NJ ENSMUSG00205006924
 protein coding gene Chr19:37084389-37149892 (-)
JF1/MsJ ENSUMUG00000037171
 protein coding gene Chr19:38307474-38370614 (-)
LP/J ENSMUSG00230032763
 protein coding gene Chr19:38928951-38994521 (-)
NOD/ShiLtJ ENSMUSG00190010154
 protein coding gene Chr19:37489893-37555493 (-)
NZO/HlLtJ ENSMUSG00225043077
 protein coding gene Chr19:42480180-42545679 (-)
PWK/PhJ ENSLUMG00010001180
 protein coding gene Chr19:37482811-37546136 (-)
SPRET/EiJ ENSMSPG00010021813
 protein coding gene Chr19:37216360-37280234 (-)
WSB/EiJ ENSIUOG00005035590
 protein coding gene Chr19:37001119-37066511 (-)



Homology
more
  • Human Ortholog
    BLNK, B cell linker
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BLNK, B cell linker
  • Synonyms
    AGM4, BASH, bca, BLNK-S, LY57, SLP-65, SLP65
  • Links
    NCBI Gene ID: 29760
    UniProt: Q8WV28

  • Chr Location
    10q24.1; chr10:96189171-96272658 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BLNK associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 6 alleles in 8 genetic backgrounds
    39 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a partial block in pre-B cell development, a lack of B1 B cells, reduced numbers of mature B cells, lower IgM and IgG3 serum levels, poor IgM immune responses, and a high incidence of pre-B cell lymphoma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    19
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17060 NCBI Gene Model | MGI Sequence Detail 65294 C57BL/6J ±  kb
    transcript NM_008528 RefSeq | MGI Sequence Detail 1783 ZRU/MplStud  
    polypeptide Q9QUN3 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11999, MGD-MRK-12042, MGI:1278314
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 62
    • Earliest
      J:2171 Rochelle JM, et al., A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics. 1992 Sep;14(1):26-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory