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Ldhb Gene Detail
Summary
  • Symbol
    Ldhb
  • Name
    lactate dehydrogenase B
  • Synonyms
    H-Ldh, lactate dehydrogenase-B, Ldh-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96763
    NCBI Gene: 16832
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142435975-142453683 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 74.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    728 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96763
 protein coding gene Chr6:142435975-142453683 (-)
129S1/SvImJ ENSMUSG00200029588
 protein coding gene Chr6:139976973-139994681 (-)
A/J ENSMUSG00195008085
 protein coding gene Chr6:138883357-138901065 (-)
AKR/J ENSMUSG00220030445
 protein coding gene Chr6:137110225-137127933 (-)
BALB/cJ ENSMUSG00180014898
 protein coding gene Chr6:139010885-139028593 (-)
C3H/HeJ ENSMUSG00175032303
 protein coding gene Chr6:138910226-138927934 (-)
C57BL/6NJ ENSMUSG00215020317
 protein coding gene Chr6:139081417-139099125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029034
 protein coding gene Chr6:140327479-140345514 (-)
CAST/EiJ ENSTCUG00005035027
 protein coding gene Chr6:139741467-139759171 (-)
CBA/J ENSMUSG00210004448
 protein coding gene Chr6:138972921-138990629 (-)
DBA/2J ENSMUSG00185022330
 protein coding gene Chr6:139623463-139641170 (-)
FVB/NJ ENSMUSG00205019493
 protein coding gene Chr6:137995852-138013731 (-)
JF1/MsJ ENSUMUG00000005394
 protein coding gene Chr6:138278792-138296498 (-)
LP/J ENSMUSG00230009495
 protein coding gene Chr6:140760111-140779746 (-)
NOD/ShiLtJ ENSMUSG00190005785
 protein coding gene Chr6:139446063-139463903 (-)
NZO/HlLtJ ENSMUSG00225013380
 protein coding gene Chr6:143613485-143631193 (-)
PWK/PhJ ENSLUMG00010028394
 protein coding gene Chr6:137362088-137379928 (-)
SPRET/EiJ ENSMSPG00010015974
 protein coding gene Chr6:141280448-141298245 (-)
WSB/EiJ ENSIUOG00005020118
 protein coding gene Chr6:139687843-139705582 (-)



Homology
more
  • Human Ortholog
    LDHB, lactate dehydrogenase B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDHB, lactate dehydrogenase B
  • Synonyms
    HEL-S-281, LDH-B, LDHBD, LDH-H, TRG-5
  • Links
    NCBI Gene ID: 3945
    UniProt: P07195

  • Chr Location
    12p12.1; chr12:21635340-21757890 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display progressive, age-related hearing loss with loss of outer hair cells, diffuse fibrocyte degeneration, and loss of spiral ganglion cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    118
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16832 NCBI Gene Model | MGI Sequence Detail 17709 C57BL/6J ±  kb
    transcript NM_008492 RefSeq | MGI Sequence Detail 1338 ZRU/MplStud  
    polypeptide P16125 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 17
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11766, MGD-MRK-11772, MGI:2141472
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 19
      Gene Ontology 16
      Phenotypes 23
    • Earliest
      J:5101 Epstein CJ, Mammalian oocytes: X chromosome activity. Science. 1969 Mar 7;163(871):1078-9
    • Latest
      J:383436 Tendulkar S, et al., Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline. PLoS One. 2026;21(4):e0347135
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory