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Itgb7 Gene Detail
Summary
  • Symbol
    Itgb7
  • Name
    integrin beta 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96616
    NCBI Gene: 16421
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102124430-102140379 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.39 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96616
 protein coding gene Chr15:102124429-102141840 (-)
129S1/SvImJ ENSMUSGG00200054868
 protein coding gene Chr15:99358808-99361703 (-)
A/J ENSMUSG00195040003
 protein coding gene Chr15:99247864-99250740 (-)
AKR/J ENSMUSGG00220054343
 protein coding gene Chr15:99218653-99221545 (-)
BALB/cJ ENSMUSGG00180055041
 protein coding gene Chr15:99130646-99133544 (-)
C3H/HeJ ENSMUSG00175042171
 protein coding gene Chr15:99449755-99452629 (-)
C57BL/6NJ ENSMUSGG00215055239
 protein coding gene Chr15:99174109-99176998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020342
 protein coding gene Chr15:96051771-96068307 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210025944
 protein coding gene Chr15:99200931-99203807 (-)
DBA/2J ENSMUSGG00185057380
 protein coding gene Chr15:99218546-99221435 (-)
FVB/NJ ENSMUSGG00205054521
 protein coding gene Chr15:98923047-98925938 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055464
 protein coding gene Chr15:102579870-102582765 (-)
NOD/ShiLtJ ENSMUSGG00190054533
 protein coding gene Chr15:99163386-99166275 (-)
NZO/HlLtJ ENSMUSGG00225055287
 protein coding gene Chr15:102759711-102762591 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ITGB7, integrin subunit beta 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB7, integrin subunit beta 7
  • Links
    NCBI Gene ID: 3695
    UniProt: P26010

  • Chr Location
    12q13.13; chr12:53191318-53207282 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    17
  • cDNA Data
    32
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001281 Ensembl Gene Model | MGI Sequence Detail 15950 C57BL/6J ±  kb
    transcript ENSMUST00000001327 Ensembl | MGI Sequence Detail 2683 Not Applicable  
    polypeptide ENSMUSP00000001327 Ensembl | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 3
      cDNA 32

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11495
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 9
      Phenotypes 96
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory