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Neurog3 Gene Detail
Summary
  • Symbol
    Neurog3
  • Name
    neurogenin 3
  • Synonyms
    Atoh5, bHLHa7, Math4B, ngn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:893591
    NCBI Gene: 11925
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61968869-61970542 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.35 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893591
 protein coding gene Chr10:61968869-61970542 (+)
129S1/SvImJ ENSMUSG00200025198
 protein coding gene Chr10:58635277-58636950 (+)
A/J ENSMUSG00195025555
 protein coding gene Chr10:58947842-58949515 (+)
AKR/J ENSMUSG00220036253
 protein coding gene Chr10:58640077-58641750 (+)
BALB/cJ ENSMUSG00180026891
 protein coding gene Chr10:58990137-58991810 (+)
C3H/HeJ ENSMUSG00175025366
 protein coding gene Chr10:58842525-58844198 (+)
C57BL/6NJ ENSMUSG00215015712
 protein coding gene Chr10:58588245-58589918 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015378
 protein coding gene Chr10:56637687-56639332 (+)
CAST/EiJ ENSTCUG00005028303
 protein coding gene Chr10:58640715-58642388 (+)
CBA/J ENSMUSG00210036239
 protein coding gene Chr10:58720829-58722502 (+)
DBA/2J ENSMUSG00185040681
 protein coding gene Chr10:59067640-59069313 (+)
FVB/NJ ENSMUSG00205021954
 protein coding gene Chr10:58741181-58742854 (+)
JF1/MsJ ENSUMUG00000011933
 protein coding gene Chr10:60304617-60306290 (+)
LP/J ENSMUSG00230016897
 protein coding gene Chr10:60870625-60872298 (+)
NOD/ShiLtJ ENSMUSG00190026475
 protein coding gene Chr10:59053258-59054931 (+)
NZO/HlLtJ ENSMUSG00225044970
 protein coding gene Chr10:65151597-65153270 (+)
PWK/PhJ ENSLUMG00010020779
 protein coding gene Chr10:58673516-58675189 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005037967
 protein coding gene Chr10:58623175-58624848 (+)



Homology
more
  • Human Ortholog
    NEUROG3, neurogenin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROG3, neurogenin 3
  • Synonyms
    Atoh5, bHLHa7, Math4B, ngn3, NGN-3
  • Links
    NCBI Gene ID: 50674
    UniProt: Q9Y4Z2

  • Chr Location
    10q22.1; chr10:69571485-69573511 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human NEUROG3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 7 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are deficient in endocrine cells of the glandular stomach and intestinal epithelium, and lack glucagon- and insulin-producing cells of the pancreas. Mutants die postnatally from diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1316
  • Tissues
    319
  • cDNA Data
    16
  • Literature Summary
    339
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11925 NCBI Gene Model | MGI Sequence Detail 1674 C57BL/6J ±  kb
    transcript NM_009719 RefSeq | MGI Sequence Detail 1540 C57BL/6  
    polypeptide P70661 UniProt | EBI | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 3
      cDNA 18
      Primer pair 23
      Other 5
      Antibodies 33

      Microarray probesets 5
    References
    more
    • Summaries
      All 507
      Developmental Gene Expression 339
      Gene Ontology 14
      Phenotypes 107
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:390194 Park J, et al., PAX4 R192H variant impairs beta cell function by disrupting beta cell identity and compensatory capacity in response to metabolic stress. Genome Med. 2026 May 28;18(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory