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Sfrp4 Gene Detail
Summary
  • Symbol
    Sfrp4
  • Name
    secreted frizzled-related protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:892010
    NCBI Gene: 20379
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:19807345-19816995 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 6.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892010
 protein coding gene Chr13:19807274-19817164 (+)
129S1/SvImJ ENSMUSG00200012093
 protein coding gene Chr13:17045853-17055710 (+)
A/J ENSMUSG00195036915
 protein coding gene Chr13:16169201-16179083 (+)
AKR/J ENSMUSG00220029566
 protein coding gene Chr13:16068860-16078750 (+)
BALB/cJ ENSMUSG00180031153
 protein coding gene Chr13:16529833-16539717 (+)
C3H/HeJ ENSMUSG00175030928
 protein coding gene Chr13:16598620-16608498 (+)
C57BL/6NJ ENSMUSG00215022430
 protein coding gene Chr13:16563742-16573632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018254
 protein coding gene Chr13:14961259-14971161 (+)
CAST/EiJ ENSTCUG00005012791
 protein coding gene Chr13:16628386-16638285 (+)
CBA/J ENSMUSG00210030265
 protein coding gene Chr13:16453226-16463100 (+)
DBA/2J ENSMUSG00185012575
 protein coding gene Chr13:17154578-17164452 (+)
FVB/NJ ENSMUSG00205023027
 protein coding gene Chr13:16325526-16335408 (+)
JF1/MsJ ENSUMUG00000012011
 protein coding gene Chr13:16889625-16899726 (+)
LP/J ENSMUSG00230033278
 protein coding gene Chr13:26569784-26579658 (+)
NOD/ShiLtJ ENSMUSG00190021772
 protein coding gene Chr13:16427066-16436940 (+)
NZO/HlLtJ ENSMUSG00225032349
 protein coding gene Chr13:20326685-20336575 (+)
PWK/PhJ ENSLUMG00010026770
 protein coding gene Chr13:15869628-15879740 (+)
SPRET/EiJ ENSMSPG00010017736
 protein coding gene Chr13:15577866-15587812 (+)
WSB/EiJ ENSIUOG00005031282
 protein coding gene Chr13:15789806-15799678 (+)



Homology
more
  • Human Ortholog
    SFRP4, secreted frizzled related protein 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFRP4, secreted frizzled related protein 4
  • Synonyms
    FRP-4, FRPHE, FRZB-2, PYL, sFRP-4
  • Links
    NCBI Gene ID: 6424
    UniProt: Q6FHJ7

  • Chr Location
    7p14.1; chr7:37905932-38025695 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SFRP4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit reduced litter size produced from female mice while mice homozygous for another exhibit hyper-fertile female mice and increased litter size. Mice homozygous for a different null allele exhibit increased trabecular bone mass, decreased compact bone thickness, and protection from age-related osteoporosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    195
  • cDNA Data
    25
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20379 NCBI Gene Model | MGI Sequence Detail 9651 C57BL/6J ±  kb
    transcript NM_016687 RefSeq | MGI Sequence Detail 1760 C57BL/6  
    polypeptide Q9Z1N6 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 25
      Primer pair 9
      Other 6
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 33
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:367124 Berube M, et al., SFRP4 promotes autophagy and blunts FSH responsiveness through inhibition of AKT signaling in ovarian granulosa cells. Cell Commun Signal. 2024 Aug 14;22(1):396
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory