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Vsx2 Gene Detail
Summary
  • Symbol
    Vsx2
  • Name
    visual system homeobox 2
  • Synonyms
    Chx10, Hox10, Hox-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:88401
    NCBI Gene: 12677
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84616602-84642231 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.28 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88401
 protein coding gene Chr12:84616536-84642231 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019940
 protein coding gene Chr12:85291734-85317422 (+)
A/J MGP_AJ_G0019897
 protein coding gene Chr12:82061021-82087985 (+)
AKR/J MGP_AKRJ_G0019873
 protein coding gene Chr12:84278503-84304035 (+)
BALB/cJ MGP_BALBcJ_G0019877
 protein coding gene Chr12:82394145-82419752 (+)
C3H/HeJ MGP_C3HHeJ_G0019683
 protein coding gene Chr12:84749200-84775775 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020328
 protein coding gene Chr12:87749013-87776513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017946
 protein coding gene Chr12:78956989-78983082 (+)
CAST/EiJ MGP_CASTEiJ_G0019232
 protein coding gene Chr12:79703529-79731436 (+)
CBA/J MGP_CBAJ_G0019654
 protein coding gene Chr12:91137829-91169205 (+)
DBA/2J MGP_DBA2J_G0019769
 protein coding gene Chr12:81585784-81611199 (+)
FVB/NJ MGP_FVBNJ_G0019755
 protein coding gene Chr12:80542795-80569551 (+)
LP/J MGP_LPJ_G0019841
 protein coding gene Chr12:85168867-85197781 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019794
 protein coding gene Chr12:94039198-94066257 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020362
 protein coding gene Chr12:83885981-83912698 (+)
PWK/PhJ MGP_PWKPhJ_G0018996
 protein coding gene Chr12:76074922-76101740 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018791
 protein coding gene Chr12:78374479-78400725 (+)
WSB/EiJ MGP_WSBEiJ_G0019284
 protein coding gene Chr12:84590169-84616837 (+)



Homology
more
  • Human Ortholog
    VSX2, visual system homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VSX2, visual system homeobox 2
  • Synonyms
    CHX10, HOX10, MCOP2, MCOPCB3, RET1
  • Links
    NCBI Gene ID: 338917
    neXtProt AC: NX_P58304
    UniProt: P58304

  • Chr Location
    14q24.3; chr14:74239449-74262738 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VSX2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 5 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    8 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous mutations exhibit microphthalmia, lack of retinal intercellular channels, and agenesis of the optic nerve. Homozygotes for one mutant allele also have a germ cell maturation defect with sterility in both sexes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1077
  • Tissues
    177
  • cDNA Data
    49
  • Literature Summary
    372
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12677 NCBI Gene Model | MGI Sequence Detail 25630 C57BL/6J ±  kb
    transcript NM_001301427 RefSeq | MGI Sequence Detail 3276 ZRU/MplStud  
    polypeptide Q61412 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 4
      cDNA 52
      Primer pair 2
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10826, MGD-MRK-13044, MGD-MRK-1983
    References
    more
    • Summaries
      All 456
      Developmental Gene Expression 372
      Gene Ontology 12
      Phenotypes 62
    • Earliest
      J:307 TRUSLOVE GM, A gene causing ocular retardation in the mouse. J Embryol Exp Morphol. 1962 Dec;10(4):652-60
    • Latest
      J:343468 Li Y, et al., Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms. iScience. 2023 Dec 15;26(12):108544
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory