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Cd28 Gene Detail
Summary
  • Symbol
    Cd28
  • Name
    CD28 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88327
    NCBI Gene: 12487
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:60785547-60812521 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 30.52 cM, cytoband C1-C3
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88327
 protein coding gene Chr1:60755959-60812521 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016079
 protein coding gene Chr1:60803491-60854866 (+)
A/J MGP_AJ_G0016062
 protein coding gene Chr1:58639659-58690015 (+)
AKR/J MGP_AKRJ_G0016018
 protein coding gene Chr1:60297644-60346809 (+)
BALB/cJ MGP_BALBcJ_G0016017
 protein coding gene Chr1:58675762-58725006 (+)
C3H/HeJ MGP_C3HHeJ_G0015849
 protein coding gene Chr1:60535151-60585552 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016470
 protein coding gene Chr1:63157518-63216713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014191
 protein coding gene Chr1:54842110-54898561 (+)
CAST/EiJ MGP_CASTEiJ_G0015431
 protein coding gene Chr1:59741836-59792912 (+)
CBA/J MGP_CBAJ_G0015821
 protein coding gene Chr1:65147627-65203584 (+)
DBA/2J MGP_DBA2J_G0015922
 protein coding gene Chr1:58074563-58124328 (+)
FVB/NJ MGP_FVBNJ_G0015924
 protein coding gene Chr1:57362133-57413296 (+)
LP/J MGP_LPJ_G0015994
 protein coding gene Chr1:61675563-61727867 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015944
 protein coding gene Chr1:68044546-68095668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016517
 protein coding gene Chr1:60223791-60275493 (+)
PWK/PhJ MGP_PWKPhJ_G0015218
 protein coding gene Chr1:57415476-57466457 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014998
 protein coding gene Chr1:59725191-59779915 (+)
WSB/EiJ MGP_WSBEiJ_G0015494
 protein coding gene Chr1:59914736-59964745 (+)



Homology
more
  • Human Ortholog
    CD28, CD28 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD28, CD28 molecule
  • Synonyms
    Tp44
  • Links
    NCBI Gene ID: 940
    neXtProt AC: NX_P10747
    UniProt: P10747

  • Chr Location
    2q33.2; chr2:203706475-203738912 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CD28 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 8 alleles in 15 genetic backgrounds
    39 phenotypes from multigenic genotypes
    3 images
    345 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impairment of some T cell responses and decreased basal immunoglobulin levels. Mutant animals have reduced T helper cell activity and impaired T cell response to lectins, but cytotoxic T cells can still be induced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    35
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12487 NCBI Gene Model | MGI Sequence Detail 26975 C57BL/6J ±  kb
    transcript NM_007642 RefSeq | MGI Sequence Detail 4317 ZRU/MplStud  
    polypeptide P31041 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1845
    References
    more
    • Summaries
      All 497
      Developmental Gene Expression 1
      Gene Ontology 23
      Phenotypes 345
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345978 Hulskotter K, et al., CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis. Front Immunol. 2023;14:1105432
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory