About   Help   FAQ
Agtr2 Gene Detail
Summary
  • Symbol
    Agtr2
  • Name
    angiotensin II receptor, type 2
  • Synonyms
    AT2 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:87966
    NCBI Gene: 11609
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:21350863-21355072 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.71 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87966
 protein coding gene ChrX:21350783-21355403 (+)
129S1/SvImJ ENSMUSG00200015267
 protein coding gene ChrX:16114253-16118873 (+)
A/J ENSMUSG00195007206
 protein coding gene ChrX:16117411-16122031 (+)
AKR/J ENSMUSG00220017816
 protein coding gene ChrX:15614976-15619597 (+)
BALB/cJ ENSMUSG00180022514
 protein coding gene ChrX:16051072-16055692 (+)
C3H/HeJ ENSMUSG00175028430
 protein coding gene ChrX:16095099-16099719 (+)
C57BL/6NJ ENSMUSG00215016742
 protein coding gene ChrX:16695746-16700366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032978
 protein coding gene ChrX:14779244-14783891 (+)
CAST/EiJ ENSTCUG00005026688
 protein coding gene ChrX:16010690-16015309 (+)
CBA/J ENSMUSG00210020247
 protein coding gene ChrX:16148008-16152628 (+)
DBA/2J ENSMUSG00185031112
 protein coding gene ChrX:22748816-22753436 (+)
FVB/NJ ENSMUSG00205018504
 protein coding gene ChrX:15692965-15697585 (+)
JF1/MsJ ENSUMUG00000022269
 protein coding gene ChrX:36587256-36591875 (+)
LP/J ENSMUSG00230005759
 protein coding gene ChrX:27324792-27329412 (+)
NOD/ShiLtJ ENSMUSG00190027244
 protein coding gene ChrX:16101369-16105989 (+)
NZO/HlLtJ ENSMUSG00225041108
 protein coding gene ChrX:32557796-32562416 (+)
PWK/PhJ ENSLUMG00010015712
 protein coding gene ChrX:15982419-15987038 (+)
SPRET/EiJ ENSMSPG00010010365
 protein coding gene ChrX:17343664-17348288 (+)
WSB/EiJ ENSIUOG00005029466
 protein coding gene ChrX:12701736-12706355 (+)



Homology
more
  • Human Ortholog
    AGTR2, angiotensin II receptor type 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGTR2, angiotensin II receptor type 2
  • Synonyms
    AT2, ATGR2, MRX88
  • Links
    NCBI Gene ID: 186
    UniProt: P50052

  • Chr Location
    Xq23; chrX:116170744-116174974 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human AGTR2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    103 phenotypes from 3 alleles in 8 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele may exhibit abnormal response to angiotensin II, induced pancreatitis, and myocardial infarction; cardiovascular morphology and physiology; renal and urinary morphology and physiology; and glucose and lipid homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    157
  • cDNA Data
    46
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11609 NCBI Gene Model | MGI Sequence Detail 4210 C57BL/6J ±  kb
    transcript NM_007429 RefSeq | MGI Sequence Detail 2872 ZRU/MplStud  
    polypeptide P35374 UniProt | EBI | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 6
      cDNA 46
      Primer pair 11
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1197, MGI:2147867, MGI:2147996
    References
    more
    • Summaries
      All 225
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 16
      Phenotypes 116
    • Earliest
      J:30921 Tsutsumi K, et al., Heterogeneity of angiotensin II AT2 receptors in the rat brain. Mol Pharmacol. 1992 Feb;41(2):290-7
    • Latest
      J:372542 Elsaafien K, et al., Neurons of the Central Nucleus of the Amygdala That Express Angiotensin Type 2 Receptors Couple Lowered Blood Pressure with Anxiolysis in Male Mice. J Neurosci. 2025 Mar 19;45(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory