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Ache Gene Detail
Summary
  • Symbol
    Ache
  • Name
    acetylcholinesterase
  • Feature Type
    protein coding gene
  • IDs
    MGI:87876
    NCBI Gene: 11423
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137286516-137292728 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.32 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87876
 protein coding gene Chr5:137285781-137292728 (+)
129S1/SvImJ ENSMUSG00200042279
 protein coding gene Chr5:131080154-131087132 (+)
A/J ENSMUSG00195048156
 protein coding gene Chr5:130582851-130589825 (+)
AKR/J ENSMUSG00220047390
 protein coding gene Chr5:130058181-130065161 (+)
BALB/cJ ENSMUSG00180035756
 protein coding gene Chr5:130679418-130686392 (+)
C3H/HeJ ENSMUSG00175044793
 protein coding gene Chr5:132606962-132613938 (+)
C57BL/6NJ ENSMUSG00215047522
 protein coding gene Chr5:130728844-130735791 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027868
 protein coding gene Chr5:130092910-130099946 (+)
CAST/EiJ ENSTCUG00005009460
 protein coding gene Chr5:129950240-129957249 (+)
CBA/J ENSMUSG00210006323
 protein coding gene Chr5:131424535-131431507 (+)
DBA/2J ENSMUSG00185052378
 protein coding gene Chr5:134439923-134446897 (+)
FVB/NJ ENSMUSG00205045112
 protein coding gene Chr5:130324363-130331337 (+)
JF1/MsJ ENSUMUG00000022503
 protein coding gene Chr5:137330297-137337278 (+)
LP/J ENSMUSG00230042925
 protein coding gene Chr5:138553405-138560377 (+)
NOD/ShiLtJ ENSMUSG00190037708
 protein coding gene Chr5:130379210-130386186 (+)
NZO/HlLtJ ENSMUSG00225023239
 protein coding gene Chr5:146228672-146235640 (+)
PWK/PhJ ENSLUMG00010017761
 protein coding gene Chr5:129186742-129193744 (+)
SPRET/EiJ ENSMSPG00010033424
 protein coding gene Chr5:132589580-132596369 (+)
WSB/EiJ ENSIUOG00005033837
 protein coding gene Chr5:133030220-133037192 (+)



Homology
more
  • Human Ortholog
    ACHE, acetylcholinesterase (Yt blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACHE, acetylcholinesterase (Yt blood group)
  • Synonyms
    ACEE, ARACHE, N-ACHE, YT
  • Links
    NCBI Gene ID: 43
    UniProt: P22303

  • Chr Location
    7q22.1; chr7:100889994-100897022 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human ACHE associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 8 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1058
  • Tissues
    184
  • cDNA Data
    27
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11423 NCBI Gene Model | MGI Sequence Detail 6213 C57BL/6J ±  kb
    transcript NM_001290010 RefSeq | MGI Sequence Detail 2227 ZRU/MplStud  
    polypeptide P21836 UniProt | EBI | MGI Sequence Detail 614 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 7
      cDNA 28
      Primer pair 10
      Other 2
      Antibodies 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1035
    References
    more
    • Summaries
      All 221
      Developmental Gene Expression 65
      Gene Ontology 20
      Phenotypes 36
    • Earliest
      J:41300 Rachinsky TL, et al., Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Neuron. 1990 Sep;5(3):317-27
    • Latest
      J:376292 Liu Y, et al., Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice. J Neurosci. 2025 Oct 29;45(44)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory