Shox2 RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:355648 Abassah-Oppong S, et al., A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival. Nat Commun. 2024 Oct 10;15(1):8793
Assay type:	RNA in situ
MGI Accession ID:	MGI:7834389
Gene symbol:	Shox2
Gene name:	SHOX homeobox 2

Probe:	Shox2 probe
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

3B WT E10.5 FL ©

Specimen 3B WT E10.5 FL: embryonic day 10.5 (more

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Structure	Level	Pattern	Image	Note
TS17: forelimb bud	Present		3B WT E10.5 FL

3B WT E10.5 HL ©

Specimen 3B WT E10.5 HL: embryonic day 10.5 (more

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Structure	Level	Pattern	Image	Note
TS17: hindlimb bud	Present		3B WT E10.5 HL

3B WT E11.5 FL ©

Specimen 3B WT E11.5 FL: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: forelimb bud	Present		3B WT E11.5 FL

3B WT E11.5 HL ©

Specimen 3B WT E11.5 HL: embryonic day 11.5 (more

)

Structure	Level	Pattern	Image	Note
TS19: hindlimb bud	Present		3B WT E11.5 HL

3B GD^delta/delta E10.5 FL ©

Specimen 3B GD^delta/delta E10.5 FL: embryonic day 10.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image	Note
TS17: forelimb bud	Present		3B GD^delta/delta E10.5 FL

3B GD^delta/delta E10.5 HL ©

Specimen 3B GD^delta/delta E10.5 HL: embryonic day 10.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image	Note
TS17: hindlimb bud	Present		3B GD^delta/delta E10.5 HL

3B GD^delta/delta E11.5 FL ©

Specimen 3B GD^delta/delta E11.5 FL: embryonic day 11.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image	Note
TS19: forelimb bud	Present		3B GD^delta/delta E11.5 FL

3B GD^delta/delta E11.5 HL ©

Specimen 3B GD^delta/delta E11.5 HL: embryonic day 11.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image	Note
TS19: hindlimb bud	Present		3B GD^delta/delta E11.5 HL

3D WT left ©

Specimen 3D WT left: embryonic day 10.5 (more

)

Structure	Level	Image
TS17: diencephalon	Present	3D WT left
TS17: facial prominence	Present	3D WT left
TS17: midbrain	Present	3D WT left
TS17: nasal process	Present	3D WT left

3D WT middle ©

Specimen 3D WT middle: embryonic day 11.5 (more

)

Structure	Level	Image
TS19: diencephalon	Present	3D WT middle
TS19: maxillary process	Present	3D WT middle
TS19: midbrain	Present	3D WT middle
TS19: nasal process	Present	3D WT middle

3D WT right ©

Specimen 3D WT right: embryonic day 11.5 (more

)

Structure	Level	Image
TS19: diencephalon	Present	3D WT right
TS19: maxillary process	Present	3D WT right
TS19: midbrain	Present	3D WT right
TS19: nasal process	Present	3D WT right

3D GD^delta/delta left ©

Specimen 3D GD^delta/delta left: embryonic day 10.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image
TS17: diencephalon	Present	Regionally restricted	3D GD^delta/delta left
TS17: midbrain	Present	Regionally restricted	3D GD^delta/delta left
TS17: medial-nasal process	Trace		3D GD^delta/delta left

Specimen 3D GD^delta/delta middle: embryonic day 11.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Pattern	Image	Note
TS19: diencephalon	Present		3D GD^delta/delta middle
TS19: midbrain	Present		3D GD^delta/delta middle
TS19: palatal shelf	Present	Regionally restricted	3D GD^delta/delta middle	Expression is downregulated in the anterior portion of the palatal shelves.
TS19: mandibular process	Weak		3D GD^delta/delta middle
TS19: medial-nasal process	Trace		3D GD^delta/delta middle

Specimen 3D GD^delta/delta right: embryonic day 11.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Image
TS19: diencephalon	Present	3D GD^delta/delta right
TS19: midbrain	Present	3D GD^delta/delta right
TS19: mandibular process	Weak	3D GD^delta/delta right
TS19: maxillary process	Weak	3D GD^delta/delta right

4A WT ©

Specimen 4A WT: embryonic day 10.5 (more

)

Structure	Level	Image
TS17: dorsal root ganglion	Present	4A WT
TS17: nodose placode	Present	4A WT
TS17: sinus venosus	Present	4A WT

Specimen 4A GD^delta/delta: embryonic day 10.5; Del(3Rr805-Rr776)2Lap/Del(3Rr805-Rr776)2Lap (more

)

Structure	Level	Image	Note
TS17: dorsal root ganglion	Present	4A GD^delta/delta	Expression in this tissue is the same as in controls.
TS17: nodose placode	Weak	4A GD^delta/delta
TS17: sinus venosus	Absent	4A GD^delta/delta

5B WT ©

Specimen 5B WT: embryonic day 10.5 (more

)

Structure	Level	Image
TS17: dorsal root ganglion	Present	5B WT
TS17: nodose placode	Present	5B WT
TS17: sinus venosus	Present	5B WT

Specimen 5B SV-Enh^delta/delta: embryonic day 10.5; Rr805^em1Mostr/Rr805^em1Mostr (more

)

Structure	Level	Image
TS17: dorsal root ganglion	Present	5B SV-Enh^delta/delta
TS17: nodose placode	Present	5B SV-Enh^delta/delta
TS17: sinus venosus	Weak	5B SV-Enh^delta/delta

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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