About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:233142 Hilton MJ, et al., Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
Assay type: RNA in situ
MGI Accession ID: MGI:7593621
Gene symbol: Ihh
Gene name: Indian hedgehog
Probe: Ihh probe
Probe preparation: Antisense RNA
Results
Specimen 3b WT: embryonic day 18.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted 3b Ihh WT Expressed in the prehypertrophic and early hypertrophic regions.
Specimen 3b PNN: embryonic day 18.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted 3b Ihh PNN Expressed in the prehypertrophic and early hypertrophic regions, and persisted at a lower level throughout much of the mutant hypertrophic zone.
TS26: epiphyseal plate hypertrophic zone Present 3b Ihh PNN Persisted at a lower level throughout much of the mutant hypertrophic zone.
Specimen 3c WT: embryonic day 14.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Ihh WT Two major expressing domains were well separated.
Specimen 3c PNN: embryonic day 14.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Ihh PNN Two major expressing domains were less well separated, compared with the control.
Specimen S3a Control E18.5: embryonic day 18.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted S3a E18.5 control Expressed in the prehypertrophic and early hypertrophic regions.
Specimen S3a PPS E18.5: embryonic day 18.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate Present Regionally restricted S3a E18.5 PPS Expressed in the prehypertrophic and early hypertrophic regions, and persisted at a lower level throughout much of the mutant hypertrophic zone.
TS26: epiphyseal plate hypertrophic zone Present S3a E18.5 PPS Persisted at a lower level throughout much of the mutant hypertrophic zone.
Specimen S3a Control E14.5: embryonic day 14.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3a E14.5 control Two major expressing domains were well separated.
Specimen S3a PPS E14.5: embryonic day 14.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3a E14.5 PPS Two major expressing domains were less well separated, compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory