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Gene Expression Data
Assay Details
Assay
Reference: J:233142 Hilton MJ, et al., Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14
Assay type: RNA in situ
MGI Accession ID: MGI:7593619
Gene symbol: Col10a1
Gene name: collagen, type X, alpha 1
Probe: Col10a1 probe
Probe preparation: Antisense RNA
Results
Specimen 3b WT: embryonic day 18.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate hypertrophic zone Present 3b Col10a1 WT
Specimen 3b PNN: embryonic day 18.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate hypertrophic zone Present 3b Col10a1 PNN Significantly longer positive hypertrophic zone, compared with the control.
Specimen 3c WT: embryonic day 14.5; Notch1tm2Rko/Notch1tm2Rko, Notch2tm3Grid/Notch2tm3Grid (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Col10a1 WT Expressed in the hypertrophic region.
Specimen 3c PNN: embryonic day 14.5; Notch1tm2Rko/Notch1tm1Con, Notch2tm3Grid/Notch2tm3Grid, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted 3c Col10a1 PNN Substantially shortened hypertrophic region compared with the control.
Specimen S3b Control E18.5: embryonic day 18.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS26: epiphyseal plate hypertrophic zone Present S3b E18.5 control
Specimen S3b PPS E18.5: embryonic day 18.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: epiphyseal plate hypertrophic zone Present S3b E18.5 PPS Significantly longer positive hypertrophic zone, compared with the control.
Specimen S3b Control E14.5: embryonic day 14.5; Psen2tm1Bdes/Psen2tm1Bdes (more )
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3b E14.5 control Expressed in the hypertrophic region.
Specimen S3b PPS E14.5: embryonic day 14.5; Psen1tm2Shn/Psen1tm2Shn, Psen2tm1Bdes/Psen2tm1Bdes, Tg(Prrx1-cre)1Cjt/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: tibia cartilage condensation Present Regionally restricted S3b E14.5 PPS Substantially shortened hypertrophic region compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory