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Gene Expression Data
Assay Details
Assay
Reference: J:206632 Roberts JM, et al., Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014 Feb 1;522(2):372-92
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7531502
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Results
Specimen 3C: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Tra2btm1.1Bwir/Tra2b+ (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Bcl11b (assay MGI:7531500); blue - Bhlhe22 (assay MGI:7531501).
Structure Cell Type Level Pattern Image Note
TS27: cerebral cortex pyramidal neuron Present Regionally restricted 3C Expression specific subtypes of projection neurons.
Specimen 3D: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Tra2btm1.1Bwir/Tra2btm1.1Bwir (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Bcl11b (assay MGI:7531500); blue - Bhlhe22 (assay MGI:7531501).
Structure Cell Type Level Pattern Image Note
TS27: cerebral cortex pyramidal neuron Weak 3D Numbers of expressing cells reduced compared to control.
Specimen 3E/F/G: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Tra2btm1.1Bwir/Tra2b+ (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Bcl11b (assay MGI:7531500); blue - Bhlhe22 (assay MGI:7531501).
Structure Cell Type Level Pattern Image Note
TS27: cortical layer VI cerebral cortex neuron Present Regionally restricted 3G , 3E , 3F Expression in corticothalamic neurons in layer 6.
TS27: cortical layer II Weak 3E , 3F , 3G Low levels expression in layers 2/3.
TS27: cortical layer III Weak 3E , 3F , 3G Low levels expression in layers 2/3.
Specimen 3J/K/L: postnatal day 0; Emx1tm1(cre)Krj/Emx1+, Tra2btm1.1Bwir/Tra2btm1.1Bwir (more )
Note: Conditional mutant. Triple labeled: green - Tbr1; red - Bcl11b (assay MGI:7531500); blue - Bhlhe22 (assay MGI:7531501).
Structure Cell Type Level Pattern Image Note
TS27: cortical layer VI cerebral cortex neuron Weak 3K , 3L , 3J Numbers of expressing cells reduced compared to control.
TS27: cortical layer II Trace 3L , 3K , 3J Layer 2/3 neurons barely detectable.
TS27: cortical layer III Trace 3L , 3K , 3J Layer 2/3 neurons barely detectable.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory