Tra2b^tm1.1Bwir
Targeted Allele Detail

Summary

• Symbol: Tra2b^tm1.1Bwir
• Name: transformer 2 beta; targeted mutation 1.1, Brunhilde Wirth
• MGI ID: MGI:4450919
• Synonyms: Sfrs10^fl
• Gene: Tra2b Location: Chr16:22063302-22084755 bp, - strand Genetic Position: Chr16, 13.18 cM
• Alliance: Tra2b^tm1.1Bwir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159448
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site and an frt flanked neomycin resistance cassette were inserted upstream of exon 4 and a second loxP site was inserted downstream of the exon. Neomycin was excised in mice by crossing to the FLP deleter line, Tg(ACTFLPe)9205Dym. Deletion of exon 4 by cre mediated excision will result in a frameshift and a premature stop codon in exon 5. (J:159448)

Expression

In Mice Carrying this Mutation:

75 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tra2b Mutation: 23 strains or lines available

References

• Original: J:159448 Mende Y, et al., Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67
• All: 9 reference(s)