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Gene Expression Data
Assay Details
Assay
Reference: J:183829 Correa SM, et al., Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
Assay type: RNA in situ
MGI Accession ID: MGI:7524461
Gene symbol: Ptch1
Gene name: patched 1
Results
Specimen 2G +/+ XX: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: ovary Absent 2G
TS21: mesonephros Present 2G
Specimen 2H +/+ XY AKR: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: gonad Strong Regionally restricted 2H Expression was restricted to central regions containing testicular cords.
Specimen 2I Wt1+/- XX: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Structure Level Pattern Image Note
TS21: ovary Absent 2I
TS21: mesonephros Present 2I Strongly reduced expression compared with the wild-type.
Specimen 2J Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads differentiated as ovotestes.
Structure Level Pattern Image Note
TS21: gonad Present Regionally restricted 2J Expressed in the central regions, but at notably lower levels than in +/+ B6 XY AKR gonads.
TS21: mesonephros Present 2J Strongly reduced expression compared with the wild-type.
Specimen not shown Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads differentiated as ovotestes.
Structure Level Pattern Image Note
TS21: gonad Present Regionally restricted Expressed in the central regions, but at notably lower levels than in +/+ B6 XY AKR gonads.
Specimen 2K Sf1+/- XX: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Structure Level Pattern Image Note
TS21: ovary Absent 2K
TS21: mesonephros Present 2K Similar as in the wild-type.
Specimen 2L Sf1+/- XY AKR: embryonic day 13.5; Nr5a1tm1Klp/Nr5a1+ (more )
Note: Gonads that developed as ovaries.
Structure Level Pattern Image Note
TS21: gonad Absent 2L Developed as ovaries, in a pattern similar to XX ovaries.
Specimen not shown Wt1+/- XY AKR: embryonic day 13.5; Wt1tm1Jae/Wt1+ (more )
Note: Gonads that developed as ovaries.
Structure Level Pattern Image Note
TS21: gonad Absent Developed as ovaries, in a pattern similar to XX ovaries.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
MGI 6.24 		The Jackson Laboratory