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Gene Expression Data
Assay Details
Assay
Reference: J:199486 Watanabe Y, et al., Sox10 and Itgb1 interaction in enteric neural crest cell migration. Dev Biol. 2013 Jul 1;379(1):92-106
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7513071
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Reporter: lacZ
Direct Detection
Results
Specimen 4A Sox10 lacZ/+: embryonic day 10.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Itgb1tm1Ref/Itgb1+, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS17: enteric nervous system migratory enteric neural crest cell Present 4A Sox10 lacZ/+
TS17: migrating neural crest migratory enteric neural crest cell Present 4A Sox10 lacZ/+
TS17: stomach migratory enteric neural crest cell Present 4A Sox10 lacZ/+
TS17: midgut migratory enteric neural crest cell Present 4A Sox10 lacZ/+ Positive cells moving in lines to colonize the midgut.
Specimen 4B Sox10 lacZ/+ left: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Itgb1tm1Ref/Itgb1+, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS19: enteric nervous system migratory enteric neural crest cell Present 4B X-gal Sox10 lacZ/+
TS19: migrating neural crest migratory enteric neural crest cell Present 4B X-gal Sox10 lacZ/+
TS19: stomach migratory enteric neural crest cell Present 4B X-gal Sox10 lacZ/+
TS19: small intestine migratory enteric neural crest cell Present Regionally restricted 4B X-gal Sox10 lacZ/+ Slight delay in colonization compared to controls, with the front of migrating enteric neural crest cells in the mutants stopping in the final quarter of the midgut.
TS19: large intestine migratory enteric neural crest cell Absent 4B X-gal Sox10 lacZ/+
Specimen 4B Sox10 lacZ/+ right: embryonic day 11.5; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Itgb1tm1Ref/Itgb1+, Sox10tm1Weg/Sox10+ (more )
Structure Level Pattern Image Note
TS19: cranial ganglion Present 4B X-gal right Sox10 lacZ/+ No obvious differences were seen.
TS19: dorsal root ganglion Present 4B X-gal right Sox10 lacZ/+ No obvious differences were seen.
TS19: peripheral nerve Present 4B X-gal right Sox10 lacZ/+ No obvious differences were seen.
Specimen 5B Sox10 lacZ/+: postnatal newborn; Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+, Itgb1tm1Ref/Itgb1+, Sox10tm1Weg/Sox10+ (more )
Structure Cell Type Level Pattern Image Note
TS27: enteric nervous system enteric neuron Present 5B Sox10 lacZ/+ lower , 5B Sox10 lacZ/+ upper
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory