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Gene Expression Data
Assay Details
Assay
Reference: J:329352 Irie M, et al., Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain. Development. 2022 Sep 15;149(18):dev200976
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7378828
Gene symbol: Rtl6
Gene name: retrotransposon Gag like 6
Reporter: Venus
Direct Detection
Results
Specimen 3 E9.0 top: embryonic day 9.0; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS14: embryo Weak 3_E9.0 top row middle
TS14: yolk sac Weak 3_E9.0 top row middle
Specimen 3 E9.0 bottom: embryonic day 9.0; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS14: embryo Weak 3_E9.0 bottom row middle
TS14: yolk sac Weak 3_E9.0 bottom row middle
Specimen 3 E12.5: embryonic day 12.5; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS20: embryo Weak 3_E12.5 middle
Specimen 3 E13.5: embryonic day 13.5; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS21: central nervous system Strong 3_E13.5 middle
Specimen 3 P0: postnatal day 0; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS27: brain Very strong 3_P0 middle
Specimen 4A top: postnatal day 1; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS27: hypothalamus Present 4A top left
Specimen 4A middle: postnatal day 1; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS27: main olfactory bulb Present 4A middle left , 4A bottom left
Specimen 4B top right: postnatal day 1; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Double labeled: green - Rtl6 reporter; red - Aif1 (assay MGI:7380249).
Structure Cell Type Level Pattern Image Note
TS27: hypothalamus microglial cell Present 4B Merge , 4B bottom left , 4B RTL6 , 4B bottom right
Specimen 5C: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Double labeled: green - Rtl6 reporter; red - Rtl5 reporter (assay MGI:7380252).
Structure Level Pattern Image Note
TS28: hypothalamus Present 5C Merge , 5C RTL6
TS28: main olfactory bulb Present 5C Merge , 5C RTL6
Specimen 5D: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Cell Type Level Pattern Image Note
TS28: hypothalamus microglial cell Weak Single cells 5D RTL6
Specimen S4B Brain: postnatal week 6; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: brain Present Punctate S4B Brain right
Specimen S4B Muscle: postnatal week 4; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: hindlimb musculature Absent S4B Muscle right
Specimen S4B Kidney: postnatal week 4; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: metanephros Absent S4B Kidney right
Specimen S4B Testis: postnatal week 4; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: seminiferous tubule Present Punctate S4B Testis right A few positive ranules were seen.
Specimen S5A: postnatal week 6; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Punctate S5A left top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
TS28: hippocampus CA1 Present Punctate S5A left top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
TS28: hippocampus CA3 Present Punctate S5A left top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
TS28: hippocampus CA2 Present Punctate S5A left bottom , S5A left top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
Specimen S5B: postnatal week 3; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Punctate S5C top , S5B top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
TS28: hippocampus Present Punctate S5C top , S5B top Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
Specimen S5D: postnatal week 6; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present Punctate S5D top Merge , S5D bottom RTL6 , S5D bottom Merge , S5D top RTL6 Expression is as small extracellular dots that accumulated alongside the pyramidal and granule cells.
Specimen S5E: postnatal week 6; Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: amygdala Present Punctate S5E left middle , S5E left bottom , S5E left top Expression is as small extracellular dots.
TS28: inferior colliculus Present Punctate S5E left middle , S5E left bottom , S5E left top Expression is as small extracellular dots.
TS28: substantia nigra Present Punctate S5E left middle , S5E left bottom , S5E left top Expression is as small extracellular dots.
Specimen S7A: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: green - Rtl6 reporter; red - Rtl5 reporter (assay MGI:7380252).; magenta - Tmem119; (assay MGI:7380256).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Present S7A RTL6
Specimen S7B: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: green - Rtl6 reporter; red - Rtl5 reporter (assay MGI:7380252); magenta - Aif1; (assay MGI:7380249).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Present S7B RTL6 , S7B Merge
Specimen S7C: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: green - Rtl6 reporter; red - Rtl5 reporter (assay MGI:7380252); magenta - Aif1; (assay MGI:7380249).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Present S7C RTL6 , S7C Merge
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory