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Gene Expression Data
Assay Details
Assay
Reference: J:329352 Irie M, et al., Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain. Development. 2022 Sep 15;149(18):dev200976
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7380252
Gene symbol: Rtl5
Gene name: retrotransposon Gag like 5
Reporter: mCherry
Direct Detection
Results
Specimen 5B: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: hypothalamus Present Single cells 5B Expression is in cells on the inner surface of the hemispheres.
TS28: main olfactory bulb Present Single cells 5B Expression is in cells on the inner surface of the hemispheres.
Specimen 5C: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Double labeled: red - Rtl5 reporter; green - Rtl6 reporter (assay MGI:7378828).
Structure Level Pattern Image Note
TS28: hypothalamus Present Single cells 5C Merge , 5C RTL5 Expression is in cells on the inner surface of the hemispheres.
TS28: main olfactory bulb Present Single cells 5C Merge , 5C RTL5 Expression is in cells on the inner surface of the hemispheres.
Specimen 5D: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Cell Type Level Pattern Image Note
TS28: hypothalamus microglial cell Present Single cells 5D RTL5 Expression was relatively higher in the round type of microglia.
Specimen S6A: postnatal week 6; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: cerebral hemisphere Present Regionally restricted S6A top right Expression is in cells on the inner surface of the hemispheres.
Specimen S6B: postnatal week 6; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Present S6B RTL5 , S6B Merge Expression is in cells on the inner surface of the hemispheres.
Specimen S6C first row: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Present Single cells S6C first row middle , S6C first row right Expression is as intracellular granules in round cells.
Specimen S6C second row: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present Single cells S6C second row right , S6C second row middle
Specimen S6C third row: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Structure Level Pattern Image Note
TS28: cerebellum Present Single cells S6C third row middle , S6C third row right
Specimen S7A: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: red - Rtl5 reporter; magenta - Tmem119 (assay MGI:7380256); green - Rtl6 reporter (assay MGI:7378828).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Present S7A RTL5 Expression was relatively higher in the round type of microglia.
Specimen S7B: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: red - Rtl5 reporter; magenta - Aif1 (assay MGI:7380249); green - Rtl6 reporter (assay MGI:7378828).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Weak S7B RTL5 , S7B Merge Expression is lower in ramified microglia.
Specimen S7C: postnatal; Rtl5em1Tmki/Rtl5em1Tmki, Rtl6tm1.1Tmki/Rtl6tm1.1Tmki (more )
Note: Triple labeled: red - Rtl5 reporter; magenta - Aif1 (assay MGI:7380249); green - Rtl6 reporter (assay MGI:7378828).
Structure Cell Type Level Pattern Image Note
TS28: brain microglial cell Weak S7C RTL5 , S7C Merge Expression is lower in elongated microglia.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory