Rtl5^em1Tmki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rtl5^em1Tmki
• Name: retrotransposon Gag like 5; endonuclease-mediated mutation 1, Tomoko Kaneko-Ishino
• MGI ID: MGI:7378510
• Synonyms: Rtl5-CmC
• Gene: Rtl5 Location: ChrX:101110150-101114910 bp, - strand Genetic Position: ChrX, 45.06 cM
• Alliance: Rtl5^em1Tmki page

Mutation origin

• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: CRISPR-targeting inserted an mCherry reporter gene downstream of the coding sequence. A T to A silent mutation was introduced into the position of Rtl5 Threonine 593 (ACT to ACA) to inhibit recutting of the genomic DNA after editing (J:329352)

Expression

In Mice Carrying this Mutation:

24 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtl5 Mutation: 4 strains or lines available

References

• Original: J:329352 Irie M, et al., Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain. Development. 2022 Sep 15;149(18):dev200976
• All: 1 reference(s)