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Gene Expression Data
Assay Details
Assay
Reference: J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6430500
Gene symbol: Arr3
Gene name: arrestin 3, retinal
Results
Specimen 5A: postnatal day 20 (more )
Note: The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 5A' , 5A Expression was detected in cone photoreceptors in the outer side of the outer nuclear layer.
Specimen 5B: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 5B' , 5B Rnf7 mutant cone photoreceptors were located ectopically in more inner positions within the outer nuclear layer.
Specimen 5C: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present Regionally restricted 5C , 5C' Some Rnf7 mutant cone photoreceptors were also located ectopically outside the outer nuclear layer, in the inner nuclear layer, inner plexiform layer or the ganglion cell layer.
Specimen 5D: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: green - Arr3; red - Otx2 (assay MGI:6430451).
Structure Level Pattern Image Note
TS28: retina layer Present Regionally restricted 5D'' , 5D The displaced Arr3-immunopositive cells were confirmed as cone photoreceptors by co-immunostaining with another cone marker, Otx2.
Specimen 5G: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: green - Arr3; red - Opn1sw (assay MGI:6430604).
Structure Level Pattern Image Note
TS28: retina layer Present Regionally restricted 5G , 5G'' The displaced Arr3-immunopositive cells were confirmed as cone photoreceptors by co-immunostaining with another cone marker, Opn1sw.
Specimen 5H': postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: green - Arr3; red - Opn1sw (assay MGI:6430604).
Structure Level Pattern Image Note
TS28: retina layer Present Regionally restricted 5H' Ectopically located cone photoreceptors were observed in the conditional mutant.
Specimen 6B: postnatal day 20 (more )
Note: Flat-mounted retina - picture taken at the cone nuclear level. The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6B Expression was detected in cone photoreceptors.
Specimen 6C: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone nuclear level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6C Expression was detected in cone photoreceptors.
Specimen 6D: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Crx-cre)352Gla/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone nuclear level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6D Expression was detected in cone photoreceptors.
Specimen 6E: postnatal day 20 (more )
Note: Flat-mounted retina - picture taken at the cone axon level. The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6E Staining of cone photoreceptors at the level of the axons.
Specimen 6F: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone axon level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6F In the conditional knockout retinas, cones were found displaced throughout the outer nuclear layer.
Specimen 6G: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Crx-cre)352Gla/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone axon level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6G In the conditional knockout retinas, cones were found displaced throughout the outer nuclear layer.
Specimen 6H: postnatal day 20 (more )
Note: Flat-mounted retina - picture taken at the cone pedicle level. The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6H Staining at the outer nuclear layer/outer plexiform layer border.
TS28: retina outer plexiform layer Present Regionally restricted 6H Staining at the outer nuclear layer/outer plexiform layer border.
Specimen 6I: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone pedicle level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6I In the conditional knockout retinas, cones were found displaced at the outer nuclear layer/outer plexiform layer border.
TS28: retina outer plexiform layer Present Regionally restricted 6I In the conditional knockout retinas, cones were found displaced at the outer nuclear layer/outer plexiform layer border.
Specimen 6J: postnatal day 20; Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Crx-cre)352Gla/0 (more )
Note: Conditional mutant. Flat-mounted retina - picture taken at the cone pedicle level.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted 6J In the conditional knockout retinas, cones were found displaced at the outer nuclear layer/outer plexiform layer border.
TS28: retina outer plexiform layer Present Regionally restricted 6J In the conditional knockout retinas, cones were found displaced at the outer nuclear layer/outer plexiform layer border.
Specimen not shown SOCS7 Wt: postnatal day 20 (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted Expression was detected in cone photoreceptors in the outer side of the outer nuclear layer.
Specimen not shown SOCS7 Mut: postnatal day 20; Socs7tm1b(EUCOMM)Wtsi/Socs7tm1b(EUCOMM)Wtsi (more )
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted The localization of cone photoreceptors was not disrupted in the knockout.
Specimen S4A: postnatal day 20 (more )
Note: Double labeled: red - Arr3; green - Lhx2 (assay MGI:6430607). The genetic background of the conditional control specimen was not specified.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Regionally restricted S4A , S4A' Expression was detected in cone photoreceptors.
Specimen S4B: postnatal day 20; Dab1tm1Cpr/Dab1+, Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Arr3; green - Lhx2 (assay MGI:6430607).
Structure Level Pattern Image Note
TS28: retina layer Present Regionally restricted S4B , S4B' Expression was detected in ectopic cone cells. A reduction in the Dab1 level in the mutant did not rescue cone displacement.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory