Socs7^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Socs7^{tm1b(EUCOMM)Wtsi}
• Name: suppressor of cytokine signaling 7; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6153950
• Gene: Socs7 Location: Chr11:97253261-97289368 bp, + strand Genetic Position: Chr11, 60.96 cM
• Alliance: Socs7^{tm1b(EUCOMM)Wtsi} page
• IMPC: Socs7 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257927
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_gt2 cassette was inserted at position 97263322 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 97264323. The critical exon(s) is/are thus flanked by loxP sites.A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:257927)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs7 Mutation: 22 strains or lines available

References

• Original: J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
• All: 2 reference(s)