Arr3 MGI Mouse Gene Detail - MGI:2159617

Symbol

Arr3
Name

arrestin 3, retinal
Synonyms

Arr4, arrestin 4, CAR, cone arrestin, mCAR, mCARFL, X-arrestin

Feature Type

protein coding gene
IDs

MGI:2159617
NCBI Gene: 170735
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:99649103-99662099 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.72 cM, cytoband C2
Mapping Data

1 experiment

SNPs within 2kb

382 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2159617	protein coding gene	ChrX:99649086-99662099 (+)
129S1/SvImJ	ENSMUSG00200037582	protein coding gene	ChrX:81361787-81374783 (+)
A/J	ENSMUSG00195039008	protein coding gene	ChrX:85123374-85136363 (+)
AKR/J	ENSMUSG00220028411	protein coding gene	ChrX:79814100-79827089 (+)
BALB/cJ	ENSMUSG00180020360	protein coding gene	ChrX:81833752-81846745 (+)
C3H/HeJ	ENSMUSG00175041127	protein coding gene	ChrX:85494246-85507231 (+)
C57BL/6NJ	ENSMUSG00215045995	protein coding gene	ChrX:82008396-82021396 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033272	protein coding gene	ChrX:94883145-94896033 (+)
CAST/EiJ	ENSTCUG00005040885	protein coding gene	ChrX:82882869-82895915 (+)
CBA/J	ENSMUSG00210037218	protein coding gene	ChrX:82265107-82278096 (+)
DBA/2J	ENSMUSG00185043410	protein coding gene	ChrX:94701290-94714290 (+)
FVB/NJ	ENSMUSG00205024906	protein coding gene	ChrX:81516902-81529887 (+)
JF1/MsJ	ENSUMUG00000023761	protein coding gene	ChrX:115295911-115308947 (+)
LP/J	ENSMUSG00230039292	protein coding gene	ChrX:101395327-101408327 (+)
NOD/ShiLtJ	ENSMUSG00190034812	protein coding gene	ChrX:81413110-81426098 (+)
NZO/HlLtJ	ENSMUSG00225044536	protein coding gene	ChrX:106486216-106499252 (+)
PWK/PhJ	ENSLUMG00010034775	protein coding gene	ChrX:80566138-80579138 (+)
SPRET/EiJ	ENSMSPG00010034751	protein coding gene	ChrX:84862470-84875699 (+)
WSB/EiJ	ENSIUOG00005041993	protein coding gene	ChrX:81959342-81972346 (+)

Human Ortholog

ARR3, arrestin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARR3, arrestin 3
Synonyms

ARRX, cArr, MYP26
Links

HGNC:710

NCBI Gene ID: 407

UniProt: P36575
Chr Location

Xq13.1; chrX:70268305-70281883 (+) GRCh38

MGI Vertebrate Homology

Arr3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARR3
Gene Tree

Arr3

Diseases

1 with human ARR3 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit normal cone electrophysiology.

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All GO Annotations

24
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

693
Tissues

12
cDNA Data

14
Literature Summary

66

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARR3

Xenbase arr3

ZFIN arr3a, arr3b

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All Sequences

80
RefSeq

45
UniProt

3
CCDS

CCDS41075.1

Ensembl

ENSMUSG00000060890 (Evidence)
NCBI Gene

170735

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060890	Ensembl Gene Model \| MGI Sequence Detail	12997	C57BL/6J	± kb
transcript	ENSMUST00000113769	Ensembl \| MGI Sequence Detail	1359	Not Applicable
polypeptide	ENSMUSP00000109398	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004318 arrestin-C

(term hierarchy)
InterPro Domains

IPR000698 Arrestin

IPR017864 Arrestin, conserved site

IPR011022 Arrestin-like, C-terminal domain

IPR014752 Arrestin-like, C-terminal domain superfamily

IPR011021 Arrestin-like, N-terminal

IPR014753 Arrestin, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 20

cDNA 14

Primer pair 5

Other 1

Antibodies 3

Microarray probesets 3

Summaries

All 120

Developmental Gene Expression 66

Gene Ontology 14

Phenotypes 16
Earliest

J:61371 Hong DH, et al., A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54
Latest

J:390147 Tu HY, et al., Transcription co-repressors Panky and Panky-like modulate ganglioside levels and are essential for retinal cone photoreceptor structure and survival. J Neurosci. 2026 Jul 16;:e0052262026

TSS for Arr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161614	ChrX:99649141-99649154 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24