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Gene Expression Data
Assay Details
Assay
Reference: J:226703 Shimada M, et al., Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358701
Gene symbol: Satb2
Gene name: special AT-rich sequence binding protein 2
Antibody: anti-SATB2 (SATBA4B10; ab51502)
Detection system: Cy3
Results
Specimen 1E Control Satb2: postnatal day 2 (more )
Note: Triple labeled: red - Satb2; green - Brn2 (Pou3f2 assay MGI:6358703); blue - DAPI.
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 1E Control Satb2 , 1E Control Merge (left) Expression in upper layer neurons.
Specimen 1E PNKP nes-cre Satb2: postnatal day 2; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Triple labeled: red - Satb2; green - Brn2 (Pou3f2 assay MGI:6358703); blue - DAPI.
Structure Level Pattern Image Note
TS27: neocortex Weak Regionally restricted 1E PNKP nes-cre Merge (left) , 1E PNKP nes-cre Satb2 Authors state the ordered six-layer lamination is maintained, but there were reduced numbers of neurons, particularly in upper cortical layers.
Specimen 3B Control Satb2: postnatal day 0; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Satb2; green - Ctip2 (Bcl11b assay MGI:6358705).
Structure Level Pattern Image Note
TS27: neocortex Strong Regionally restricted 3B Control Merge , 3B Control Satb2 Expression in upper layer neurons.
Specimen 3B Pnkp Nes-Cre Satb2: postnatal day 0; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Satb2; green - Ctip2 (Bcl11b assay MGI:6358705).
Structure Level Pattern Image Note
TS27: neocortex Weak Regionally restricted 3B Pnkp Nes-Cre Merge , 3B Pnkp Nes-Cre Satb2
Specimen 3B (Pnkp;p53) Nes-Cre Satb2: postnatal day 0; Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0, Trp53tm1Tyj/Trp53tm1Tyj (more )
Note: Conditional mutant. Double labeled: red - Satb2; green - Ctip2 (Bcl11b assay MGI:6358705).
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted 3B (Pnkp:p53) Nes-Cre Satb2 , 3B (Pnkp;p53) Nes-Cre Merge Authors report recovery of neuronal numbers and a more ordered cortical lamination.
Specimen 3B (Pnkp;Atm) Nes-Cre Satb2: postnatal day 0; Atmtm2Pmc/Atmtm2Pmc, Pnkptm1.1Pmc/Pnkptm1.1Pmc, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant. Double labeled: red - Satb2; green - Ctip2 (Bcl11b assay MGI:6358705).
Structure Level Pattern Image Note
TS27: neocortex Weak Regionally restricted 3B (Pnkp;Atm) Nes-Cre Merge , 3B (Pnkp;Atm) Nes-Cre Satb2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory