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H3f4 Gene Detail
Summary
  • Symbol
    H3f4
  • Name
    H3.4 histone, cluster member
  • Synonyms
    Gm12260, H304, H3mmT, H3t
  • Feature Type
    protein coding gene
  • IDs
    MGI:3651326
    NCBI Gene: 382523
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:58852537-58853099 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 36.39 cM
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3651326
 protein coding gene Chr11:58852537-58853364 (+)
129S1/SvImJ MGP_129S1SvImJ_G0039971
 pseudogene Chr11:58743629-58744039 (+)
A/J MGP_AJ_G0039978
 pseudogene Chr11:56503244-56503654 (+)
AKR/J MGP_AKRJ_G0039898
 pseudogene Chr11:58403704-58404114 (+)
BALB/cJ MGP_BALBcJ_G0039956
 pseudogene Chr11:56870194-56870604 (+)
C3H/HeJ MGP_C3HHeJ_G0039603
 pseudogene Chr11:58291067-58291477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0040535
 pseudogene Chr11:60619625-60620035 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0037092
 pseudogene Chr11:53775781-53776191 (+)
CAST/EiJ MGP_CASTEiJ_G0038711
 pseudogene Chr11:58408520-58408930 (+)
CBA/J MGP_CBAJ_G0039572
 pseudogene Chr11:63264511-63264921 (+)
DBA/2J MGP_DBA2J_G0039769
 pseudogene Chr11:56181020-56181430 (+)
FVB/NJ MGP_FVBNJ_G0039733
 pseudogene Chr11:55828948-55829358 (+)
LP/J MGP_LPJ_G0039805
 pseudogene Chr11:59359315-59359725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0039718
 pseudogene Chr11:64419248-64419658 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0040626
 pseudogene Chr11:58408516-58408926 (+)
PWK/PhJ MGP_PWKPhJ_G0038389
 pseudogene Chr11:56766220-56766630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0038120
 pseudogene Chr11:58216503-58216913 (+)
WSB/EiJ MGP_WSBEiJ_G0038933
 pseudogene Chr11:58093701-58094111 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility associated with small testes, meiotic failure, increased male germ cell apoptosis, and azoospermia.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      25
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382523 NCBI Gene Model | MGI Sequence Detail 563 C57BL/6J ±  kb
    transcript NM_001318003 RefSeq | MGI Sequence Detail 563 C57BL/6  
    polypeptide NP_001304932 RefSeq | MGI Sequence Detail 136 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    References
    more
    • Summaries
      All 13
      Phenotypes 4
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:258191 Ueda J, et al., Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. Cell Rep. 2017 Jan 17;18(3):593-600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory