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Zfhx2 Gene Detail
Summary
  • Symbol
    Zfhx2
  • Name
    zinc finger homeobox 2
  • Synonyms
    zfh-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686934
    NCBI Gene: 239102
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55297719-55329781 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686934
 protein coding gene Chr14:55297719-55329875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021339
 protein coding gene Chr14:49061170-49093251 (-)
A/J MGP_AJ_G0021298
 protein coding gene Chr14:48080722-48112751 (-)
AKR/J MGP_AKRJ_G0021274
 protein coding gene Chr14:49830331-49862336 (-)
BALB/cJ MGP_BALBcJ_G0021302
 protein coding gene Chr14:48058339-48090371 (-)
C3H/HeJ MGP_C3HHeJ_G0021082
 protein coding gene Chr14:49518877-49552451 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021740
 protein coding gene Chr14:51549313-51581885 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019287
 protein coding gene Chr14:46485820-46518025 (-)
CAST/EiJ MGP_CASTEiJ_G0020601
 protein coding gene Chr14:45766197-45801536 (-)
CBA/J MGP_CBAJ_G0021049
 protein coding gene Chr14:53104780-53136838 (-)
DBA/2J MGP_DBA2J_G0021170
 protein coding gene Chr14:47820705-47852748 (-)
FVB/NJ MGP_FVBNJ_G0021152
 protein coding gene Chr14:47287468-47319449 (-)
LP/J MGP_LPJ_G0021244
 protein coding gene Chr14:50110966-50143781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021176
 protein coding gene Chr14:52470119-52502158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021767
 protein coding gene Chr14:49014996-49046988 (-)
PWK/PhJ MGP_PWKPhJ_G0020348
 protein coding gene Chr14:44360542-44392782 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020176
 protein coding gene Chr14:44997567-45038650 (-)
WSB/EiJ MGP_WSBEiJ_G0020654
 protein coding gene Chr14:49310050-49343545 (-)



Homology
more
  • Human Ortholog
    ZFHX2, zinc finger homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFHX2, zinc finger homeobox 2
  • Synonyms
    MARSIS, ZFH5, ZFH-5, ZNF409
  • Links
    NCBI Gene ID: 85446
    neXtProt AC: NX_Q9C0A1
    UniProt: Q9C0A1

  • Chr Location
    14q11.2; chr14:23520857-23556192 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zfhx2 mouse models; 1 with human ZFHX2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    87
  • cDNA Data
    11
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040721 Ensembl Gene Model | MGI Sequence Detail 32063 C57BL/6J ±  kb
    transcript ENSMUST00000036328 Ensembl | MGI Sequence Detail 10397 Not Applicable  
    polypeptide ENSMUSP00000045156 Ensembl | MGI Sequence Detail 2562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 11
      Primer pair 8
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:326542 van de Haar LL, et al., Molecular signatures and cellular diversity during mouse habenula development. Cell Rep. 2022 Jul 5;40(1):111029
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory