Phenotypes Associated with This Genotype

Genotype
MGI:7329779

• Allelic Composition: Zfhx2^tm3Ymri/Zfhx2^tm3Ymri
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased mechanical nociceptive threshold ( J:266472 )

• mice are hyposensitive to noxious mechanical stimuli applied to the tail but with normal sensitivity to innocuous touch

decreased thermal nociceptive threshold ( J:266472 )

• in the hot-plate test, mice are hypersensitive to noxious hea

nervous system

abnormal nervous system electrophysiology ( J:266472 )

• deep dorsal horn wide dynamic range neuron recordings show reduced evoked activity of neurons after mechanical stimuli indicating a deficit in noxious mechanical coding

• however, no differences in response to dynamic low threshold stimuli are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Marsili syndrome		DOID:0081075	OMIM:147430	J:266472