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Hmcn2 Gene Detail
Summary
  • Symbol
    Hmcn2
  • Name
    hemicentin 2
  • Synonyms
    MGC:31312, MGC:49669
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677838
    NCBI Gene: 665700
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31204427-31350750 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677838
 protein coding gene Chr2:31204273-31350751 (+)
129S1/SvImJ ENSMUSG00200052952
 protein coding gene Chr2:28175522-28321863 (+)
A/J ENSMUSG00195044700
 protein coding gene Chr2:28271179-28362743 (+)
AKR/J ENSMUSG00220051964
 protein coding gene Chr2:28389132-28535393 (+)
BALB/cJ ENSMUSG00180054118
 protein coding gene Chr2:28288575-28434922 (+)
C3H/HeJ ENSMUSG00175051744
 protein coding gene Chr2:28257990-28404315 (+)
C57BL/6NJ ENSMUSG00215043445
 protein coding gene Chr2:28323422-28469764 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023411
 protein coding gene Chr2:27190721-27337756 (+)
CAST/EiJ ENSTCUG00005052750
 protein coding gene Chr2:28003621-28149557 (+)
CBA/J ENSMUSG00210015225
 protein coding gene Chr2:28330630-28476961 (+)
DBA/2J ENSMUSG00185044096
 protein coding gene Chr2:28184526-28276086 (+)
FVB/NJ ENSMUSG00205033376
 protein coding gene Chr2:28036689-28182949 (+)
JF1/MsJ ENSUMUG00000052229
 protein coding gene Chr2:28088978-28235106 (+)
LP/J ENSMUSG00230043976
 protein coding gene Chr2:30111136-30257461 (+)
NOD/ShiLtJ ENSMUSG00190051375
 protein coding gene Chr2:28291263-28382819 (+)
NZO/HlLtJ ENSMUSG00225007040
 protein coding gene Chr2:37862803-38008815 (+)
PWK/PhJ ENSLUMG00010041291
 protein coding gene Chr2:28171528-28316940 (+)
SPRET/EiJ ENSMSPG00010034334
 protein coding gene Chr2:28885627-29030980 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HMCN2, hemicentin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMCN2, hemicentin 2
  • Links
    NCBI Gene ID: 256158
    UniProt: Q8NDA2

  • Chr Location
    9q34.11; chr9:130265760-130434123 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele are viable and fertile with no gross abnormalities. Mice homozygous for a second null allele display heart ventricle, hematocrit and hemoglobin abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    30
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055632 Ensembl Gene Model | MGI Sequence Detail 146324 C57BL/6J ±  kb
    transcript ENSMUST00000113532 Ensembl | MGI Sequence Detail 15646 Not Applicable  
    polypeptide ENSMUSP00000109160 Ensembl | MGI Sequence Detail 5100 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR050958 Cell Adhesion and Cytoskeletal Organization
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR006605 G2 nidogen/fibulin G2F
      IPR009017 Green fluorescent protein
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR056861 Hemicentin-1-like, von Willebrand factor A domain
      IPR056475 Hemicentin/VWA7, galactose-binding domain-like
      IPR003599 Immunoglobulin domain subtype
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003598 Immunoglobulin subtype 2
      IPR013106 Immunoglobulin V-set domain
      IPR049883 NOTCH1, EGF-like calcium-binding domain
      IPR036465 von Willebrand factor A-like domain superfamily
    • GlyGen
      A2AJ76 44 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14
      Antibodies 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory