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Nanos2 Gene Detail
Summary
  • Symbol
    Nanos2
  • Name
    nanos C2HC-type zinc finger 2
  • Synonyms
    nos2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676627
    NCBI Gene: 378430
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18721449-18722887 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676627
 protein coding gene Chr7:18721325-18722887 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031750
 protein coding gene Chr7:16928126-16929688 (+)
A/J MGP_AJ_G0031726
 protein coding gene Chr7:16627119-16628681 (+)
AKR/J MGP_AKRJ_G0031652
 protein coding gene Chr7:17082329-17083891 (+)
BALB/cJ MGP_BALBcJ_G0031731
 protein coding gene Chr7:16819722-16821284 (+)
C3H/HeJ MGP_C3HHeJ_G0031453
 protein coding gene Chr7:17335638-17337200 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032197
 protein coding gene Chr7:17813950-17815512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029263
 protein coding gene Chr7:18273295-18274855 (+)
CAST/EiJ MGP_CASTEiJ_G0030796
 protein coding gene Chr7:13740101-13741665 (+)
CBA/J MGP_CBAJ_G0031415
 protein coding gene Chr7:18464615-18466177 (+)
DBA/2J MGP_DBA2J_G0031570
 protein coding gene Chr7:16560753-16562315 (+)
FVB/NJ MGP_FVBNJ_G0031522
 protein coding gene Chr7:16421566-16423128 (+)
LP/J MGP_LPJ_G0031653
 protein coding gene Chr7:17272126-17273688 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031558
 protein coding gene Chr7:18320841-18322403 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032225
 protein coding gene Chr7:16682609-16684171 (+)
PWK/PhJ MGP_PWKPhJ_G0030520
 protein coding gene Chr7:13644785-13646345 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030347
 protein coding gene Chr7:11373010-11374569 (+)
WSB/EiJ MGP_WSBEiJ_G0030896
 protein coding gene Chr7:16888108-16889670 (+)



Homology
more
  • Human Ortholog
    NANOS2, nanos C2HC-type zinc finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NANOS2, nanos C2HC-type zinc finger 2
  • Synonyms
    NOS2, ZC2HC12B
  • Links
    NCBI Gene ID: 339345
    neXtProt AC: NX_P60321
    UniProt: P60321

  • Chr Location
    19q13.32; chr19:45913214-45914778 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Whereas homozygous mutant female mice are fertile and show no morphological or functional abnormalities of the ovaries, the testes of homozygous mutant male mice are reduced in weight and devoid of germ cells. The spermatogenic defects appear to be associated with increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    136
  • cDNA Data
    5
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 378430 NCBI Gene Model | MGI Sequence Detail 1439 C57BL/6J ±  kb
    transcript NM_194064 RefSeq | MGI Sequence Detail 1439 Not Specified  
    polypeptide P60322 UniProt | EBI | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 5
      Primer pair 7

      Microarray probesets 1
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 41
      Gene Ontology 11
      Phenotypes 29
    • Earliest
      J:86522 Tsuda M, et al., Conserved role of nanos proteins in germ cell development. Science. 2003 Aug 29;301(5637):1239-41
    • Latest
      J:333802 Singh N, et al., LHX2 in germ cells control tubular organization in the developing mouse testis. Exp Cell Res. 2023 Feb 14;425(1):113511
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory