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P2ry6 Gene Detail
Summary
  • Symbol
    P2ry6
  • Name
    pyrimidinergic receptor P2Y, G-protein coupled, 6
  • Synonyms
    2010204J23Rik, P2Y6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673874
    NCBI Gene: 233571
  • Alliance
    genome feature page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100586837-100623856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1294 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673874
 protein coding gene Chr7:100586837-100628528 (-)
129S1/SvImJ ENSMUSG00200048496
 protein coding gene Chr7:87416425-87443134 (-)
A/J ENSMUSG00195053100
 protein coding gene Chr7:91921930-91948640 (-)
AKR/J ENSMUSG00220051079
 protein coding gene Chr7:85338567-85365278 (-)
BALB/cJ ENSMUSG00180030002
 protein coding gene Chr7:88594877-88621584 (-)
C3H/HeJ ENSMUSG00175023750
 protein coding gene Chr7:89250960-89278301 (-)
C57BL/6NJ ENSMUSG00215019262
 protein coding gene Chr7:88433126-88459904 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030056
 protein coding gene Chr7:103614851-103640701 (-)
CAST/EiJ ENSTCUG00005052171
 protein coding gene Chr7:91836867-91867438 (-)
CBA/J ENSMUSG00210024805
 protein coding gene Chr7:89104497-89131842 (-)
DBA/2J ENSMUSG00185055810
 protein coding gene Chr7:93426112-93453457 (-)
FVB/NJ ENSMUSG00205024554
 protein coding gene Chr7:89093075-89119792 (-)
JF1/MsJ ENSUMUG00000029741
 protein coding gene Chr7:98331269-98358665 (-)
LP/J ENSMUSG00230041309
 protein coding gene Chr7:99558196-99584899 (-)
NOD/ShiLtJ ENSMUSG00190020696
 protein coding gene Chr7:89373353-89399951 (-)
NZO/HlLtJ ENSMUSG00225049114
 protein coding gene Chr7:97735960-97762447 (-)
PWK/PhJ ENSLUMG00010044515
 protein coding gene Chr7:87582112-87609453 (-)
SPRET/EiJ ENSMSPG00010010622
 protein coding gene Chr7:88822419-88824816 (-)
WSB/EiJ ENSIUOG00005010446
 protein coding gene Chr7:89722216-89748755 (-)



Homology
more
  • Human Ortholog
    P2RY6, pyrimidinergic receptor P2Y6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY6, pyrimidinergic receptor P2Y6
  • Synonyms
    P2Y6
  • Links
    NCBI Gene ID: 5031
    UniProt: Q15077

  • Chr Location
    11q13.4; chr11:73264498-73305103 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal macrophage, endothelial, and vascular smooth muscle response to UTP and UDP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    14
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048779 Ensembl Gene Model | MGI Sequence Detail 37020 C57BL/6J ±  kb
    transcript ENSMUST00000060174 Ensembl | MGI Sequence Detail 1946 Not Applicable  
    polypeptide ENSMUSP00000055697 Ensembl | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913795
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 48
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:385722 Skovsted GF, et al., Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries. Exp Physiol. 2026 Mar;111(3):1524-1542
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory