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Ercc6l Gene Detail
Summary
  • Symbol
    Ercc6l
  • Name
    excision repair cross-complementing rodent repair deficiency complementation group 6 like
  • Synonyms
    D330021P09Rik, MGC:7766
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654144
    NCBI Gene: 236930
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101186426-101200697 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 45.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2654144
 protein coding gene ChrX:101185322-101200697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035970
 protein coding gene ChrX:98721438-98738089 (-)
A/J MGP_AJ_G0035955
 protein coding gene ChrX:98675955-98691624 (-)
AKR/J MGP_AKRJ_G0035871
 protein coding gene ChrX:101527908-101547371 (-)
BALB/cJ MGP_BALBcJ_G0035940
 protein coding gene ChrX:97417623-97433506 (-)
C3H/HeJ MGP_C3HHeJ_G0035648
 protein coding gene ChrX:99097487-99113776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036468
 protein coding gene ChrX:101638232-101659714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033297
 protein coding gene ChrX:96390776-96405244 (-)
CAST/EiJ MGP_CASTEiJ_G0034934
 protein coding gene ChrX:83407728-83430572 (-)
CBA/J MGP_CBAJ_G0035622
 protein coding gene ChrX:104794672-104809700 (-)
DBA/2J MGP_DBA2J_G0035776
 protein coding gene ChrX:97899214-97915169 (-)
FVB/NJ MGP_FVBNJ_G0035715
 protein coding gene ChrX:97259340-97275834 (-)
LP/J MGP_LPJ_G0035867
 protein coding gene ChrX:99639662-99654639 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035749
 protein coding gene ChrX:109320792-109335269 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036494
 protein coding gene ChrX:98366433-98382802 (-)
PWK/PhJ MGP_PWKPhJ_G0034633
 protein coding gene ChrX:80986781-81002537 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034461
 protein coding gene ChrX:84320548-84337234 (-)
WSB/EiJ MGP_WSBEiJ_G0035073
 protein coding gene ChrX:97080252-97095589 (-)



Homology
more
  • Human Ortholog
    ERCC6L, ERCC excision repair 6 like, spindle assembly checkpoint helicase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERCC6L, ERCC excision repair 6 like, spindle assembly checkpoint helicase
  • Synonyms
    PICH, RAD26L
  • Links
    NCBI Gene ID: 54821
    neXtProt AC: NX_Q2NKX8
    UniProt: Q2NKX8

  • Chr Location
    Xq13.1; chrX:72204657-72239027 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 1 genetic background
    5 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a kncok-out allele exhibit chromosomal instability, Trp53 activation, increased embryonic tissue cell and brain apoptosis, developmental arrest and complete embryonic lethality, whereas heterozygous females are born at sub-Mendelian ratios and show reduced female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    19
  • cDNA Data
    70
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 236930 NCBI Gene Model | MGI Sequence Detail 14272 C57BL/6J ±  kb
    transcript NM_146235 RefSeq | MGI Sequence Detail 4198 C57BL/6  
    polypeptide Q8BHK9 UniProt | EBI | MGI Sequence Detail 1240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 70
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2384292, MGI:2443488
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339248 Geng X, et al., PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response. Adv Sci (Weinh). 2022 Mar;9(7):e2103837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory