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Sidt2 Gene Detail
Summary
  • Symbol
    Sidt2
  • Name
    SID1 transmembrane family, member 2
  • Synonyms
    CGI-40, MGC:36407, MGC:58967
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446134
    NCBI Gene: 214597
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45849155-45866556 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446134
 protein coding gene Chr9:45849155-45869299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034745
 protein coding gene Chr9:44543708-44560726 (-)
A/J MGP_AJ_G0034726
 protein coding gene Chr9:43282705-43299870 (-)
AKR/J MGP_AKRJ_G0034653
 protein coding gene Chr9:44165886-44183156 (-)
BALB/cJ MGP_BALBcJ_G0034717
 protein coding gene Chr9:43006769-43024028 (-)
C3H/HeJ MGP_C3HHeJ_G0034428
 protein coding gene Chr9:44643694-44660798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035238
 protein coding gene Chr9:45820607-45837847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032152
 protein coding gene Chr9:42821018-42838162 (-)
CAST/EiJ MGP_CASTEiJ_G0033750
 protein coding gene Chr9:44492128-44511252 (-)
CBA/J MGP_CBAJ_G0034400
 protein coding gene Chr9:47499811-47516950 (-)
DBA/2J MGP_DBA2J_G0034559
 protein coding gene Chr9:43156897-43174156 (-)
FVB/NJ MGP_FVBNJ_G0034500
 protein coding gene Chr9:42423653-42441150 (-)
LP/J MGP_LPJ_G0034640
 protein coding gene Chr9:44859799-44878138 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034544
 protein coding gene Chr9:49277407-49294673 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035259
 protein coding gene Chr9:44080731-44097969 (-)
PWK/PhJ MGP_PWKPhJ_G0033455
 protein coding gene Chr9:43064649-43084091 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033291
 protein coding gene Chr9:44404126-44421074 (-)
WSB/EiJ MGP_WSBEiJ_G0033863
 protein coding gene Chr9:44128689-44145815 (-)



Homology
more
  • Human Ortholog
    SIDT2, SID1 transmembrane family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIDT2, SID1 transmembrane family member 2
  • Synonyms
    CGI-40
  • Links
    NCBI Gene ID: 51092
    neXtProt AC: NX_Q8NBJ9
    UniProt: Q8NBJ9

  • Chr Location
    11q23.3; chr11:117178736-117197445 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sidt2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 2 genetic backgrounds
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit male-specific decreased body weight and size, impaired glucose tolerance, increased serum glucose, decreased serum insulin and decreased insule granule release from beta cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    6
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034908 Ensembl Gene Model | MGI Sequence Detail 17402 C57BL/6J ±  kb
    transcript ENSMUST00000114573 Ensembl | MGI Sequence Detail 4012 Not Applicable  
    polypeptide ENSMUSP00000110220 Ensembl | MGI Sequence Detail 853 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:306839 Nguyen TA, et al., SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development. iScience. 2019 Oct 25;20:14-24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory