About   Help   FAQ
Numa1 Gene Detail
Summary
  • Symbol
    Numa1
  • Name
    nuclear mitotic apparatus protein 1
  • Synonyms
    6720401E04Rik, NuMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443665
    NCBI Gene: 101706
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101583318-101664171 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443665
protein coding gene Chr7:101583169-101664171 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032595
protein coding gene Chr7:104992699-105041123 (+)
A/J MGP_AJ_G0032571
protein coding gene Chr7:102317632-102363064 (+)
AKR/J MGP_AKRJ_G0032507
protein coding gene Chr7:104769677-104814765 (+)
BALB/cJ MGP_BALBcJ_G0032582
protein coding gene Chr7:102010362-102057473 (+)
C3H/HeJ MGP_C3HHeJ_G0032296
protein coding gene Chr7:105137246-105182969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033079
protein coding gene Chr7:108958429-109007227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030073
protein coding gene Chr7:104675353-104719558 (+)
CAST/EiJ MGP_CASTEiJ_G0031622
protein coding gene Chr7:96700388-96748205 (+)
CBA/J MGP_CBAJ_G0032262
protein coding gene Chr7:112723920-112769441 (+)
DBA/2J MGP_DBA2J_G0032414
protein coding gene Chr7:100643152-100688647 (+)
FVB/NJ MGP_FVBNJ_G0032370
protein coding gene Chr7:100430532-100475370 (+)
LP/J MGP_LPJ_G0032503
protein coding gene Chr7:106311829-106356153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032404
protein coding gene Chr7:114047905-114094890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033101
protein coding gene Chr7:104036712-104081795 (+)
PWK/PhJ MGP_PWKPhJ_G0031340
protein coding gene Chr7:93759388-93803742 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031184
protein coding gene Chr7:91333217-91383529 (+)
WSB/EiJ MGP_WSBEiJ_G0031739
protein coding gene Chr7:104728057-104771656 (+)



Homology
more
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Synonyms
    NMP-22, NUMA
  • Links
    NCBI Gene ID: 4926
    neXtProt AC: NX_Q14980
    UniProt: Q14980

  • Chr Location
    11q13.4; chr11:72002864-72080693 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human NUMA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066306 Ensembl Gene Model | MGI Sequence Detail 80854 C57BL/6J ±  kb
transcript ENSMUST00000084852 Ensembl | MGI Sequence Detail 7180 Not Applicable  
polypeptide ENSMUSP00000081912 Ensembl | MGI Sequence Detail 2094 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000011503 nuclear mitotic apparatus protein 1
  • InterPro Domains
    IPR048726 Nuclear mitotic apparatus protein 1, LGN binding domain
    IPR048724 Nuclear mitotic apparatus protein 1, N-terminal hook domain
Molecular
Reagents
less
  • All nucleic 264
    cDNA 263
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2137869, MGI:2142083, MGI:2142110
References
more
  • Summaries
    All 75
    Developmental Gene Expression 20
    Gene Ontology 11
    Phenotypes 23
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:338401 Nutter CA, et al., Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1. Brain. 2023 May 5;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory