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Numa1 Gene Detail
Summary
  • Symbol
    Numa1
  • Name
    nuclear mitotic apparatus protein 1
  • Synonyms
    6720401E04Rik, NuMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443665
    NCBI Gene: 101706
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101583318-101664171 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1616 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443665
 protein coding gene Chr7:101583169-101664171 (+)
129S1/SvImJ ENSMUSGG00200054422
 protein coding gene Chr7:88468394-88491851 (+)
129S1/SvImJ ENSMUSG00200045204
 protein coding gene Chr7:88492707-88506495 (+)
A/J ENSMUSGG00195055506
 protein coding gene Chr7:92974052-92997530 (+)
A/J ENSMUSG00195054482
 protein coding gene Chr7:92998386-93012176 (+)
AKR/J ENSMUSG00220048001
 protein coding gene Chr7:86415069-86428858 (+)
AKR/J ENSMUSGG00220054932
 protein coding gene Chr7:86390702-86414213 (+)
BALB/cJ ENSMUSGG00180055164
 protein coding gene Chr7:89647002-89670475 (+)
BALB/cJ ENSMUSG00180031365
 protein coding gene Chr7:89671331-89685119 (+)
C3H/HeJ ENSMUSGG00175054961
 protein coding gene Chr7:90301642-90323300 (+)
C3H/HeJ ENSMUSG00175021283
 protein coding gene Chr7:90324156-90337966 (+)
C57BL/6NJ ENSMUSGG00215055315
 protein coding gene Chr7:89473610-89496660 (+)
C57BL/6NJ ENSMUSG00215029311
 protein coding gene Chr7:89497516-89511306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030073
 protein coding gene Chr7:104675353-104719558 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210024881
 protein coding gene Chr7:90177569-90191379 (+)
CBA/J ENSMUSGG00210054803
 protein coding gene Chr7:90155054-90176713 (+)
DBA/2J ENSMUSGG00185057939
 protein coding gene Chr7:94476850-94498508 (+)
DBA/2J ENSMUSG00185056179
 protein coding gene Chr7:94499364-94513174 (+)
FVB/NJ ENSMUSG00205027275
 protein coding gene Chr7:90169531-90183318 (+)
FVB/NJ ENSMUSGG00205054199
 protein coding gene Chr7:90145186-90168675 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230043262
 protein coding gene Chr7:100602642-100616428 (+)
LP/J ENSMUSGG00230055523
 protein coding gene Chr7:100580230-100601786 (+)
NOD/ShiLtJ ENSMUSG00190019051
 protein coding gene Chr7:90441936-90455728 (+)
NOD/ShiLtJ ENSMUSGG00190054744
 protein coding gene Chr7:90417871-90441080 (+)
NZO/HlLtJ ENSMUSGG00225055585
 protein coding gene Chr7:98815241-98836808 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010011235
 protein coding gene Chr7:89868587-89912378 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMA1, nuclear mitotic apparatus protein 1
  • Synonyms
    NMP-22, NUMA
  • Links
    NCBI Gene ID: 4926
    UniProt: Q14980

  • Chr Location
    11q13.4; chr11:72002860-72080693 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out or hypomorphic allele exhibit embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    156
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    28
  • cDNA Data
    263
  • Literature Summary
    22
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066306 Ensembl Gene Model | MGI Sequence Detail 80854 C57BL/6J ±  kb
transcript ENSMUST00000084852 Ensembl | MGI Sequence Detail 7180 Not Applicable  
polypeptide ENSMUSP00000081912 Ensembl | MGI Sequence Detail 2094 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000011503 nuclear mitotic apparatus protein 1
    (term hierarchy)
  • InterPro Domains
    IPR048726 Nuclear mitotic apparatus protein 1, LGN binding domain
    IPR048724 Nuclear mitotic apparatus protein 1, N-terminal hook domain
    IPR051841 Nuclear mitotic apparatus protein 1-related
  • GlyGen
    E9Q7G0 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
Molecular
Reagents
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  • All nucleic 265
    cDNA 263
    Primer pair 2
    Antibodies 2

    Microarray probesets 4
Other
Accession IDs
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MGI:2137869, MGI:2142083, MGI:2142110
References
more
  • Summaries
    All 90
    Developmental Gene Expression 22
    Gene Ontology 13
    Phenotypes 24
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory