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Siglecg Gene Detail
Summary
  • Symbol
    Siglecg
  • Name
    sialic acid binding Ig-like lectin G
  • Synonyms
    A630096C01Rik, mSiglec-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443630
    NCBI Gene: 243958
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43057623-43067773 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    404 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443630
 protein coding gene Chr7:43057623-43067782 (+)
129S1/SvImJ ENSMUSG00200027339
 protein coding gene Chr7:30643235-30653387 (+)
A/J ENSMUSG00195045556
 protein coding gene Chr7:34683364-34693521 (+)
AKR/J ENSMUSG00220043623
 protein coding gene Chr7:28981470-28991624 (+)
BALB/cJ ENSMUSG00180040695
 protein coding gene Chr7:31558870-31569032 (+)
C3H/HeJ ENSMUSG00175025452
 protein coding gene Chr7:32079188-32089338 (+)
C57BL/6NJ ENSMUSG00215042033
 protein coding gene Chr7:31348980-31359137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029616
 protein coding gene Chr7:44656817-44666676 (+)
CAST/EiJ ENSTCUG00005046587
 protein coding gene Chr7:35069170-35077656 (+)
CBA/J ENSMUSG00210037362
 protein coding gene Chr7:32455968-32466124 (+)
DBA/2J ENSMUSG00185045046
 protein coding gene Chr7:36318763-36328762 (+)
FVB/NJ ENSMUSG00205043514
 protein coding gene Chr7:32001122-32011276 (+)
JF1/MsJ ENSUMUG00000046610
 protein coding gene Chr7:40805671-40815670 (+)
LP/J ENSMUSG00230049221
 protein coding gene Chr7:41762844-41772980 (+)
NOD/ShiLtJ ENSMUSG00190045910
 protein coding gene Chr7:32322840-32332997 (+)
NZO/HlLtJ ENSMUSG00225008269
 protein coding gene Chr7:39968983-39979144 (+)
PWK/PhJ ENSLUMG00010036061
 protein coding gene Chr7:31232900-31242967 (+)
SPRET/EiJ ENSMSPG00010031144
 protein coding gene Chr7:31039164-31049119 (+)
WSB/EiJ ENSIUOG00005027830
 protein coding gene Chr7:32891252-32901408 (+)



Homology
more
  • Human Ortholog
    SIGLEC10, sialic acid binding Ig like lectin 10
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC10, sialic acid binding Ig like lectin 10
  • Synonyms
    PRO940, SIGLEC-10, SLG2
  • Links
    NCBI Gene ID: 89790
    UniProt: Q96LC7

  • Chr Location
    19q13.41; chr19:51410020-51417803 (-)  GRCh38
  • Human Ortholog
    SIGLEC11, sialic acid binding Ig like lectin 11
  • Links
    NCBI Gene ID: 114132
    UniProt: Q96RL6

  • Chr Location
    19q13.33; chr19:49948971-49961172 (-)  GRCh38
  • Human Ortholog
    SIGLEC16, sialic acid binding Ig like lectin 16 (gene/pseudogene)
  • Synonyms
    Siglec-P16, SIGLECP16
  • Links
    NCBI Gene ID: 400709
    UniProt: A6NMB1

  • Chr Location
    19q13.33; chr19:49969600-49975819 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased B-1 cell numbers, increased IgM levels and IgM-producing plasma cells, and produce more IgM autoantibodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243958 NCBI Gene Model | MGI Sequence Detail 10151 C57BL/6J ±  kb
    transcript NR_175813 RefSeq | MGI Sequence Detail 2604 C57BL/6  
    polypeptide Q80ZE3 UniProt | EBI | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003599 Immunoglobulin domain subtype
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003598 Immunoglobulin subtype 2
      IPR013106 Immunoglobulin V-set domain
      IPR051036 Sialic acid-binding Ig-like lectin
      IPR061941 Sialic acid binding Ig-like lectin, C-terminal domain
    • GlyGen
      Q80ZE3 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:380709 Meng Z, et al., Signal Transducer Nanoparticles Enable Siglec-10/G Blockade Immunotherapy for Breast Cancer Treatment. Adv Mater. 2025 Oct;37(39):e2502758
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory