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Taf2 Gene Detail
Summary
  • Symbol
    Taf2
  • Name
    TATA-box binding protein associated factor 2
  • Synonyms
    150kDa, 4732460C16Rik, CIF150, TAF2B, TAFII150
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443028
    NCBI Gene: 319944
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:54878527-54935548 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 21.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1589 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443028
 protein coding gene Chr15:54878525-54935580 (-)
129S1/SvImJ ENSMUSG00200027030
 protein coding gene Chr15:51861030-51918028 (-)
A/J ENSMUSG00195005988
 protein coding gene Chr15:51897179-51953905 (-)
AKR/J ENSMUSG00220020642
 protein coding gene Chr15:51904744-51961449 (-)
BALB/cJ ENSMUSG00180008952
 protein coding gene Chr15:51844038-51901060 (-)
C3H/HeJ ENSMUSG00175004459
 protein coding gene Chr15:52102615-52159633 (-)
C57BL/6NJ ENSMUSG00215008791
 protein coding gene Chr15:51841945-51898970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019794
 protein coding gene Chr15:49172665-49230195 (-)
CAST/EiJ ENSTCUG00005006870
 protein coding gene Chr15:51735083-51792309 (-)
CBA/J ENSMUSG00210007115
 protein coding gene Chr15:51929813-51986843 (-)
DBA/2J ENSMUSG00185026237
 protein coding gene Chr15:51905779-51962493 (-)
FVB/NJ ENSMUSG00205006258
 protein coding gene Chr15:51750798-51807525 (-)
JF1/MsJ ENSUMUG00000017295
 protein coding gene Chr15:51727915-51785336 (-)
LP/J ENSMUSG00230006126
 protein coding gene Chr15:55222545-55279544 (-)
NOD/ShiLtJ ENSMUSG00190016113
 protein coding gene Chr15:51903301-51960317 (-)
NZO/HlLtJ ENSMUSG00225028570
 protein coding gene Chr15:55549529-55606551 (-)
PWK/PhJ ENSLUMG00010026493
 protein coding gene Chr15:51968693-52026014 (-)
SPRET/EiJ ENSMSPG00010022888
 protein coding gene Chr15:53047737-53105501 (-)
WSB/EiJ ENSIUOG00005006245
 protein coding gene Chr15:51932299-51989324 (-)



Homology
more
  • Human Ortholog
    TAF2, TATA-box binding protein associated factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF2, TATA-box binding protein associated factor 2
  • Synonyms
    CIF150, MRT40, TAF2B, TAFII150
  • Links
    NCBI Gene ID: 6873
    UniProt: Q6P1X5

  • Chr Location
    8q24.12; chr8:119730774-119832863 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TAF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in the liver show signs of liver inflammation and fibrosis and increased susceptibility to induced liver cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    625
  • Tissues
    17
  • cDNA Data
    97
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037343 Ensembl Gene Model | MGI Sequence Detail 57022 C57BL/6J ±  kb
    transcript ENSMUST00000041733 Ensembl | MGI Sequence Detail 5031 Not Applicable  
    polypeptide ENSMUSP00000043733 Ensembl | MGI Sequence Detail 1198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016025 transcription initiation factor TFIID subunit 2
      (term hierarchy)
    • InterPro Domains
      IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy
      IPR016024 Armadillo-type fold
      IPR027268 Peptidase M4/M1, CTD superfamily
      IPR037813 Transcription initiation factor TFIID subunit 2
      IPR057345 Transcription initiation factor TFIID subunit 2, Ig-like domain
      IPR057991 Transcription initiation factor TFIID subunit 2, TPR repeats
    • GlyGen
      Q8C176 2 sites
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 97
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145997
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:376591 Reghupaty SC, et al., TATA-box binding protein-associated factor 2 (TAF2) in hepatocyte survival and tumorigenesis. Hepatology. 2025 May 19;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory