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Dennd1a Gene Detail
Summary
  • Symbol
    Dennd1a
  • Name
    DENN domain containing 1A
  • Synonyms
    6030446I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442794
    NCBI Gene: 227801
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:37689003-38177402 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442794
 protein coding gene Chr2:37689002-38177417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025700
 protein coding gene Chr2:36518229-37029015 (-)
A/J MGP_AJ_G0025677
 protein coding gene Chr2:35024273-35509055 (-)
AKR/J MGP_AKRJ_G0025647
 protein coding gene Chr2:36181087-36677680 (-)
BALB/cJ MGP_BALBcJ_G0025672
 protein coding gene Chr2:35081790-35561450 (-)
C3H/HeJ MGP_C3HHeJ_G0025433
 protein coding gene Chr2:36101772-36598468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026118
 protein coding gene Chr2:37553941-38065863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023523
 protein coding gene Chr2:33688512-34163172 (-)
CAST/EiJ MGP_CASTEiJ_G0024896
 protein coding gene Chr2:36025125-36539205 (-)
CBA/J MGP_CBAJ_G0025412
 protein coding gene Chr2:38959856-39498366 (-)
DBA/2J MGP_DBA2J_G0025544
 protein coding gene Chr2:34766860-35257323 (-)
FVB/NJ MGP_FVBNJ_G0025506
 protein coding gene Chr2:34645562-35123650 (-)
LP/J MGP_LPJ_G0025631
 protein coding gene Chr2:36410789-36912673 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025537
 protein coding gene Chr2:38562905-39115942 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026176
 protein coding gene Chr2:36066316-36569382 (-)
PWK/PhJ MGP_PWKPhJ_G0024638
 protein coding gene Chr2:34663994-35155130 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024443
 protein coding gene Chr2:36185281-36687271 (-)
WSB/EiJ MGP_WSBEiJ_G0024964
 protein coding gene Chr2:36247075-36738417 (-)



Homology
more
  • Human Ortholog
    DENND1A, DENN domain containing 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND1A, DENN domain containing 1A
  • Synonyms
    FAM31A, KIAA1608
  • Links
    NCBI Gene ID: 57706
    neXtProt AC: NX_Q8TEH3
    UniProt: Q8TEH3

  • Chr Location
    9q33.3; chr9:123379654-123930152 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis, small brain size due to reduced proliferation, delayed PGC migration, and impaired hepatic cell proliferation, the differentiation of hepatocyte, and hepatic hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    7
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035392 Ensembl Gene Model | MGI Sequence Detail 488400 C57BL/6J ±  kb
    transcript ENSMUST00000102787 Ensembl | MGI Sequence Detail 4342 Not Applicable  
    polypeptide ENSMUSP00000099848 Ensembl | MGI Sequence Detail 1016 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:276703 Shi J, et al., Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory