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Adap1 Gene Detail
Summary
  • Symbol
    Adap1
  • Name
    ArfGAP with dual PH domains 1
  • Synonyms
    4930431P11Rik, Centa1, centaurin alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442201
    NCBI Gene: 231821
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139257631-139311377 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442201
 protein coding gene Chr5:139257631-139311516 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030279
 protein coding gene Chr5:144228765-144293536 (-)
A/J MGP_AJ_G0030248
 protein coding gene Chr5:138124600-138179022 (-)
AKR/J MGP_AKRJ_G0030180
 protein coding gene Chr5:142430673-142485546 (-)
BALB/cJ MGP_BALBcJ_G0030265
 protein coding gene Chr5:139372074-139428048 (-)
C3H/HeJ MGP_C3HHeJ_G0029976
 protein coding gene Chr5:143200734-143256095 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030710
 protein coding gene Chr5:149551421-149614309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027928
 protein coding gene Chr5:131985097-132039988 (-)
CAST/EiJ MGP_CASTEiJ_G0029381
 protein coding gene Chr5:142611060-142669884 (-)
CBA/J MGP_CBAJ_G0029946
 protein coding gene Chr5:155718235-155773993 (-)
DBA/2J MGP_DBA2J_G0030096
 protein coding gene Chr5:137938598-137992931 (-)
FVB/NJ MGP_FVBNJ_G0030051
 protein coding gene Chr5:137040473-137098078 (-)
LP/J MGP_LPJ_G0030182
 protein coding gene Chr5:144850214-144906535 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030082
 protein coding gene Chr5:158402009-158458844 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030750
 protein coding gene Chr5:142237260-142296481 (-)
PWK/PhJ MGP_PWKPhJ_G0029096
 protein coding gene Chr5:136932835-136988872 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028932
 protein coding gene Chr5:139921593-139982438 (-)
WSB/EiJ MGP_WSBEiJ_G0029455
 protein coding gene Chr5:143001974-143063050 (-)



Homology
more
  • Human Ortholog
    ADAP1, ArfGAP with dual PH domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAP1, ArfGAP with dual PH domains 1
  • Synonyms
    CENTA1, GCS1L, p42IP4
  • Links
    NCBI Gene ID: 11033
    neXtProt AC: NX_O75689
    UniProt: O75689

  • Chr Location
    7p22.3; chr7:897900-955407 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased dendritic spine density and spine structural plasticity in hippocampal neurons, enhanced long term potentiation, and improved hippocampus-dependent spatial memory in a location recognition task.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    8
  • cDNA Data
    28
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056413 Ensembl Gene Model | MGI Sequence Detail 53747 C57BL/6J ±  kb
transcript ENSMUST00000110865 Ensembl | MGI Sequence Detail 2557 Not Applicable  
polypeptide ENSMUSP00000106489 Ensembl | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:314906 Khang R, et al., Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory