About   Help   FAQ
Gak Gene Detail
Summary
  • Symbol
    Gak
  • Name
    cyclin G associated kinase
  • Synonyms
    D130045N16Rik, MGC:31204
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442153
    NCBI Gene: 231580
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108717277-108777621 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1478 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442153
 protein coding gene Chr5:108716973-108777643 (-)
129S1/SvImJ ENSMUSG00200021778
 protein coding gene Chr5:102466837-102527160 (-)
A/J ENSMUSG00195030515
 protein coding gene Chr5:101923688-101984022 (-)
AKR/J ENSMUSG00220050223
 protein coding gene Chr5:101474130-101534459 (-)
BALB/cJ ENSMUSG00180040524
 protein coding gene Chr5:102076508-102136851 (-)
C3H/HeJ ENSMUSG00175034688
 protein coding gene Chr5:104123625-104185531 (-)
C57BL/6NJ ENSMUSG00215022527
 protein coding gene Chr5:102120258-102180601 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027523
 protein coding gene Chr5:101449355-101512817 (-)
CAST/EiJ ENSTCUG00005020992
 protein coding gene Chr5:101359048-101419390 (-)
CBA/J ENSMUSG00210037678
 protein coding gene Chr5:102881214-102943114 (-)
DBA/2J ENSMUSG00185045415
 protein coding gene Chr5:105781085-105841393 (-)
FVB/NJ ENSMUSG00205034501
 protein coding gene Chr5:101807845-101869758 (-)
JF1/MsJ ENSUMUG00000012143
 protein coding gene Chr5:108838210-108899257 (-)
LP/J ENSMUSG00230029006
 protein coding gene Chr5:110007866-110068187 (-)
NOD/ShiLtJ ENSMUSG00190026498
 protein coding gene Chr5:101776066-101836404 (-)
NZO/HlLtJ ENSMUSG00225025196
 protein coding gene Chr5:117629729-117690056 (-)
PWK/PhJ ENSLUMG00010036139
 protein coding gene Chr5:100824286-100885871 (-)
SPRET/EiJ ENSMSPG00010044722
 protein coding gene Chr5:103939153-103998880 (-)
WSB/EiJ ENSIUOG00005038825
 protein coding gene Chr5:104504031-104564245 (-)



Homology
more
  • Human Ortholog
    GAK, cyclin G associated kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAK, cyclin G associated kinase
  • Synonyms
    DNAJ26, DNAJC26
  • Links
    NCBI Gene ID: 2580
    UniProt: O14976

  • Chr Location
    4p16.3; chr4:849275-932411 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 4 alleles in 6 genetic backgrounds
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of the kinase domain display neonatal lethality with abnormal lung alveolar morphology and development. Mice homozygous for a knock-out allele exhibit lethality during early development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    37
  • cDNA Data
    148
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062234 Ensembl Gene Model | MGI Sequence Detail 60345 C57BL/6J ±  kb
    transcript ENSMUST00000046603 Ensembl | MGI Sequence Detail 4453 Not Applicable  
    polypeptide ENSMUSP00000036705 Ensembl | MGI Sequence Detail 1305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 149

      Microarray probesets 5
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:365520 Zhang S, et al., Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/alpha-synuclein degradation. Autophagy. 2025 May;21(5):1039-1058
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory