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Ffar2 Gene Detail
Summary
  • Symbol
    Ffar2
  • Name
    free fatty acid receptor 2
  • Synonyms
    Gpr43
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441731
    NCBI Gene: 233079
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30517778-30523200 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441731
 protein coding gene Chr7:30517773-30523200 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032046
 protein coding gene Chr7:29844934-29850361 (-)
A/J MGP_AJ_G0032023
 protein coding gene Chr7:29022174-29027597 (-)
AKR/J MGP_AKRJ_G0031956
 protein coding gene Chr7:29766075-29771498 (-)
BALB/cJ MGP_BALBcJ_G0032030
 protein coding gene Chr7:29215841-29221264 (-)
C3H/HeJ MGP_C3HHeJ_G0031749
 protein coding gene Chr7:30235829-30242257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032496
 protein coding gene Chr7:30817603-30824521 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029546
 protein coding gene Chr7:30043783-30049238 (-)
CAST/EiJ MGP_CASTEiJ_G0031083
 protein coding gene Chr7:23491485-23498935 (-)
CBA/J MGP_CBAJ_G0031715
 protein coding gene Chr7:32297731-32305308 (-)
DBA/2J MGP_DBA2J_G0031867
 protein coding gene Chr7:28770931-28776971 (-)
FVB/NJ MGP_FVBNJ_G0031824
 protein coding gene Chr7:28887218-28892631 (-)
LP/J MGP_LPJ_G0031948
 protein coding gene Chr7:30165676-30171132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031860
 protein coding gene Chr7:31507567-31512994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032524
 protein coding gene Chr7:29281211-29289002 (-)
PWK/PhJ MGP_PWKPhJ_G0030807
 protein coding gene Chr7:23796018-23801571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030642
 protein coding gene Chr7:20284377-20289802 (-)
WSB/EiJ MGP_WSBEiJ_G0031193
 protein coding gene Chr7:29684786-29691078 (-)



Homology
more
  • Human Ortholog
    FFAR2, free fatty acid receptor 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FFAR2, free fatty acid receptor 2
  • Synonyms
    FFA2R, GPR43
  • Links
    NCBI Gene ID: 2867
    neXtProt AC: NX_O15552
    UniProt: O15552

  • Chr Location
    19q13.12; chr19:35443907-35451767 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 7 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered granulocyte and neutrophil physiology and increased inflammation in models of induced colitis, arthritis and asthma, whereas homozygotes for a different null allele show reduced neutrophil recruitment and decreased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    5
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233079 NCBI Gene Model | MGI Sequence Detail 5423 C57BL/6J ±  kb
    transcript NM_146187 RefSeq | MGI Sequence Detail 2292 C57BL/6  
    polypeptide Q8VCK6 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 61
    • Earliest
      J:299685 Andrade SP, et al., Sponge-induced angiogenesis in mice and the pharmacological reactivity of the neovasculature quantitated by a fluorimetric method. Microvasc Res. 1997 Nov;54(3):253-61
    • Latest
      J:347030 Mishra SP, et al., Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function. JCI Insight. 2024 Feb 8;9(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory